Please see the link below to for the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/613/c6645pis.pdf
C6645
Cytosine β-D-arabinofuranoside hydrochloride
≥99% (HPLC), synthetic (inorganic), crystalline
Synonym(s):
Arabinosylcytosine hydrochloride, 1-(β-D-Arabinofuranosyl)cytosine hydrochloride, Ara-C hydrochloride, Arabinocytidine hydrochloride, Cytarabine hydrochloride, Cytosine arabinoside hydrochloride
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 mg | Check Cart for Availability | $60.10 | |
| 100 mg | Check Cart for Availability | $80.90 | |
| 500 mg | Available to ship TODAYfromMILWAUKEE | $286.00 | |
| 1 g | Available to ship TODAYfromMILWAUKEE | $441.00 $374.85 | |
| 5 g | Available to ship TODAYfromMILWAUKEE | $1,540.00 |
About This Item
Empirical Formula (Hill Notation):
C9H13N3O5 · HCl
CAS Number:
Molecular Weight:
279.68
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-713-9
MDL number:
UNSPSC Code:
12352208
Assay:
≥99% (HPLC)
Biological source:
synthetic (inorganic)
Form:
crystalline
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
2-8°C
$60.10
Check Cart for Availability
Product Name
Cytosine β-D-arabinofuranoside hydrochloride, crystalline
biological source
synthetic (inorganic)
Quality Segment
assay
≥99% (HPLC)
form
crystalline
mp
197-198 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
InChI
1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
InChI key
KCURWTAZOZXKSJ-JBMRGDGGSA-N
Gene Information
Application
Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM)[1] and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.
Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
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This Item | |||
|---|---|---|---|
| biological source synthetic (inorganic) | biological source - | biological source synthetic (organic) | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 100 |
| assay ≥99% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (titration) | assay ≥98% (HPLC) |
| form crystalline | form crystalline | form powder or crystals | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility water: 50 mg/mL, clear, colorless | solubility - | solubility water: 50 mg/mL, clear, colorless to very faintly yellow | solubility water: 1 mM |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C6645-5G | 04061833511466 |
| C6645-100MG | 04061833511435 |
| C6645-500MG | 04061833511459 |
| C6645-25MG | 04061833511442 |
| C6645-1G | 04061826744178 |
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Hi I need the insert of this product please. Can you send me please? the batch number is SLCD2059
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