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  • Stereoselectivity in the salt-cocrystal products formed by phenylglycinol or phenylglycine with their respective sodium or hydrochloride salts.

Stereoselectivity in the salt-cocrystal products formed by phenylglycinol or phenylglycine with their respective sodium or hydrochloride salts.

Chirality (2012-09-22)
Harry G Brittain
ABSTRAKT

The salt and stereoselective cocrystal phenomena associated with 2-phenylglycinol and 2-phenylglycine have been studied using X-ray powder diffraction and differential scanning calorimetry. The chiral identities of the free acids and their sodium salts, or the free bases and their chloride salts, were found to play a determining role as to whether a salt-cocrystal product could or could not be formed. In particular, when cocrystallization of an enantiomerically pure basic or zwitterionic substance with its enantiomerically pure acid addition salt was attempted, a salt-cocrystal was only obtained when the absolute configuration of the two reactants is opposite. On the other hand, it has been found that no stereoselectivity in salt-cocrystal formation existed in the cocrystallization of an enantiomerically pure acidic or zwitterionic substance with its enantiomerically pure base addition salt.

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
D−(−)-α-Phenylglycine, 99%
Sigma-Aldrich
L−(+)-α-Phenylglycine, 99%
Sigma-Aldrich
2-Phenylglycine, 95%
Sigma-Aldrich
N-(2-Hydroxyethyl)aniline, 98%