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T7705
Thimet Oligopeptidase from Bacillus licheniformis
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 100 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1770,00 zł |
1770,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócGeneral description
Thimet oligopeptidase is considered essential in the degradation of collagen in collaboration with collagenolytic enzymes. Thimet oligopeptidase (TOP) is a neuropeptidase involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis. [1]
Application
Thimet oligopeptidase can be used for the degradation of collagen in combination with collagenases. It can also be used for the hydrolysis of neuropeptides such as bradykin, neurotensin, and amyliod-β-peptide. Thimet oligopeptidase has been used in a study to investigate the effect of acute cocaine administration in male rats on TOP specific activity and mRNA levels in prosencephalic brain areas related with the reward circuitry: ventral striatum, hippocampus, and frontal cortex. [2]
Preparation Note
This enzyme has been affinity chromatographically purified using a niquel affinity column. It contains a 6-Histidine tag in its C-terminus.
A working solution of this enzyme can be prepared in 20 mM phosphate buffered saline solution, pH 7.0, or sterile and deionized water, pH 7.0.
A working solution of this enzyme can be prepared in 20 mM phosphate buffered saline solution, pH 7.0, or sterile and deionized water, pH 7.0.
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Ta pozycja | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form glycerol solution (50%) | form saline solution | form solution |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −70°C |
| mol wt ~77 kDa | mol wt - | mol wt 57.6 kDa | mol wt 81.6 kDa |
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant expressed in E. coli |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Skin Irrit. 2
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Lisa A Bruce et al.
Neuropeptides, 46(4), 167-172 (2012-06-08)
Thimet oligopeptidase (TOP) and prolyl endopeptidase (PEP) are neuropeptidases involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis. GnRH is regulated in part by feedback from steroid hormones such as estradiol. Previously, we demonstrated that
Kirsty Cleverly et al.
Reproduction (Cambridge, England), 139(2), 319-330 (2009-09-17)
LHRH (GNRH) was first isolated in the mammalian hypothalamus and shown to be the primary regulator of the reproductive neuroendocrine axis comprising of the hypothalamus, pituitary and gonads. LHRH acts centrally through its initiation of pituitary gonadotrophin release. Since its
Fernanda M Cunha et al.
The Journal of biological chemistry, 283(36), 24448-24459 (2008-07-12)
Protein degradation by the ubiquitin proteasome system releases large amounts of oligopeptides within cells. To investigate possible functions for these intracellularly generated oligopeptides, we fused them to a cationic transactivator peptide sequence using reversible disulfide bonds, introduced them into cells
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| T7705-100UN | 04061831160314 |