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Merck

T1147

Sigma-Aldrich

apo-Transferrin human

apo-Transferrin human

powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)

Synonim(y):

Human transferrin, Siderophilin

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100 MG
1260,00 zł
500 MG
3040,00 zł
5 X 100 MG
3590,00 zł
1 G
5240,00 zł

1260,00 zł


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Wybierz wielkość

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100 MG
1260,00 zł
500 MG
3040,00 zł
5 X 100 MG
3590,00 zł
1 G
5240,00 zł

About This Item

Numer CAS:
Numer WE:
Numer MDL:
Kod UNSPSC:
12352202
NACRES:
NA.75

1260,00 zł


Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności

Poproś o zamówienie zbiorcze

pochodzenie biologiczne

human plasma

Poziom jakości

linia produktu

BioReagent

Próba

≥98% (agarose gel electrophoresis)

Formularz

powder

masa cząsteczkowa

76-81 kDa

stężenie

~25 mM

metody

cell culture | mammalian: suitable

zanieczyszczenia

HIV and HBsAg, source material tested negative
≤0.005% iron

rozpuszczalność

H2O: 50 mg/mL

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

−20°C

informacje o genach

human ... TF(7018)

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Zastosowanie

Apo-Transferrin human can be supplemented with iron or used to bind free iron present in media. It is also used to transport iron into mammalian cells.

Działania biochem./fizjol.

Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human apo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Apo-transferrin can be loaded with iron prior to use or added directly to an iron containing medium.

Inne uwagi

Non-heme iron-transport protein.

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Giang D Nguyen et al.
PloS one, 9(5), e96858-e96858 (2014-05-08)
H1 linker histone proteins are essential for the structural and functional integrity of chromatin and for the fidelity of additional epigenetic modifications. Deletion of H1c, H1d and H1e in mice leads to embryonic lethality by mid-gestation with a broad spectrum
Giang D Nguyen et al.
PloS one, 8(8), e72698-e72698 (2013-08-24)
Huntington's disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individual involvement has not been adequately explored.
Kathleen N O'Guin et al.
ASN neuro, 6(1), e00135-e00135 (2014-01-31)
The molecular requirements for human myelination are incompletely defined, and further study is needed to fully understand the cellular mechanisms involved during development and in demyelinating diseases. We have established a human co-culture model to study myelination. Our earlier observations
Kamil Strzelak et al.
Analytica chimica acta, 995, 43-51 (2017-11-12)
The Multicommutated Flow Analysis (MCFA) system for the estimation of clinical iron parameters: Serum Iron (SI), Unsaturated Iron Binding Capacity (UIBC) and Total Iron Binding Capacity (TIBC) has been proposed. The developed MCFA system based on simple photometric detection of
William J Buchser et al.
PloS one, 7(6), e38101-e38101 (2012-06-16)
Trauma to the spinal cord and brain can result in irreparable loss of function. This failure of recovery is in part due to inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans (CSPGs). Peripheral nervous system (PNS) neurons exhibit

Produkty

Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.

Questions

1–3 of 3 Questions  
  1. Is this product sterile and can be used directly in cell culture media or does it have to be filtered first?

    1 answer
    1. This product is suitable for cell culture. Aqueous solutions of apo-transferrin should be stable at 4°C for 5–10 days. Solutions should be filter-sterilized for maximum stability. For more information, please refer to the product information sheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/136/004/t1147pis.pdf

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  2. What is the carbohydrate content of human transferrin?

    1 answer
    1. We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  1. Cambridge UK
    • Reviews 3
    • Vote 1
    5 out of 5 stars.

    Cell culture supplement

    Supports neural stem and progenitor cell maintenance.

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  2. 1 Ratings-Only Review

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