SML2968

JA2131

≥98% (HPLC)

• Synonim(y): 1,3,6,9-Tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-2H-purin-2-one, NSC 98003, NSC98003
• Wzór empiryczny (zapis Hilla): C₁₃H₁₉N₅O₂S₂
• Numer CAS: 6505-99-3
• Masa cząsteczkowa: 341.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Właściwości

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S(CCN3CCOCC3)c1[nH]c2c(n1)N(C(=O)N(C2=S)C)C
• InChI: 1S/C13H19N5O2S2/c1-16-10-9(11(21)17(2)13(16)19)14-12(15-10)22-8-5-18-3-6-20-7-4-18/h3-8H2,1-2H3,(H,14,15)
• InChI key: XHNSOGDMSSHQFY-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

JA2131 is a cell penetrant, potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor that selectively kills cancer cells. JA2131 induces PARP1 hyper-PARylation and sensitizes cancer cells to radiation-induced DNA damage. JA2131 induces replication fork defects.

cell penetrant, potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable