SML2346

Ganciclovir

≥99% (HPLC), DMSO solution, viral DNA elongation inhibitor

• Synonim(y): Ganciclovir ready made solution, 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
• Wzór empiryczny (zapis Hilla): C₉H₁₃N₅O₄
• Numer CAS: 82410-32-0
• Masa cząsteczkowa: 255.23
• Numer MDL: MFCD12197280
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Nazwa produktu: Ganciclovir ready made solution, ≥99% (HPLC), 10 mM in DMSO
• Próba: ≥99% (HPLC)
• Formularz: DMSO solution
• stężenie: 10 mM in DMSO
• temp. przechowywania: 2-8°C
• ciąg SMILES: [n]1(c2[nH]c(n[c](c2nc1)=O)N)COC(CO)CO
• InChI: 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
• Klucz InChI: IRSCQMHQWWYFCW-UHFFFAOYSA-N

Opis

Zastosowanie

Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells.[1] It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells.[2]

Działania biochem./fizjol.

Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation.[3] Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. [4] It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations.[3]

Inne uwagi

Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H340
• Zwroty wskazujące środki ostrożności: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Klasyfikacja zagrożeń: Muta. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 188.6 °F - closed cup
• Temperatura zapłonu (°C): 87 °C - closed cup