SMB00915

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)

≥95% (HPLC)

• Synonim(y): BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester
• Wzór empiryczny (zapis Hilla): C₂₅H₄₀O₅
• Numer CAS: 27240-87-5
• Masa cząsteczkowa: 420.58
• Kod UNSPSC: 41141802
• NACRES: NA.25

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: powder
• kolor: white to beige
• mp: 153.5—154.5 °C
• rozpuszczalność: chloroform: 20 mg/mL, colorless to light yellow
• temp. przechowywania: 2-8°C

Opis

Opis ogólny

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.

Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.

Zastosowanie

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.

Cechy i korzyści

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable