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SAB4300397

Sigma-Aldrich

Anti-MYOD1 (Ab-200) antibody produced in rabbit

affinity isolated antibody

Synonim(y):

Anti-MYF3 antibody produced in rabbit, Anti-MYOD antibody produced in rabbit, Anti-PUM antibody produced in rabbit, Anti-bHLHc1 antibody produced in rabbit, Anti-myogenic differentiation 1 antibody produced in rabbit

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About This Item

Numer MDL:
MFCD01323984
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

masa cząsteczkowa

~40 kDa

reaktywność gatunkowa

mouse, human, rat

stężenie

1 mg/mL

metody

western blot: 1:500-1:1000

izotyp

IgG

sekwencja immunogenna

(A-S-S-P-R)

numer dostępu NCBI

NP_002469.2

numer dostępu UniProt

P15172

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... MYOD1(4654)

Opis ogólny

MYOD1 (myogenic differentiation 1) gene codes for a nuclear protein, that is a member of the basic helix-loop-helix (bHLH) family of transcription factors and the myogenic factors subfamily. It is located on human chromosome 11p15.1.

Immunogen

Peptide sequence around aa. 198!202 (A-S-S-P-R), according to the protein MYOD1.

Działania biochem./fizjol.

Lack of MyoD (myogenic differentiation) results in a perinatally lethal fetal akinesia. It brings histone-modifying enzymes, which help to induce muscle differentiation.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Opis wartości docelowych

MyoD encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.

Postać fizyczna

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia
Watson CM, et al.
Journal of medical Genetics, 53(4), 264-269 (2016)
Katalin Gyurina et al.
International journal of molecular sciences, 24(23) (2023-12-09)
Stimulation of thermogenesis by inducing uncoupling protein 1 (UCP1) expression in adipocytes is thought to promote weight loss by increasing energy expenditure, and it is postulated that the human newborn has thermogenic subcutaneous fat depots. However, it remains unclear whether
Manuela Dos Santos et al.
Advances in rheumatology (London, England), 62(1), 27-27 (2022-07-23)
Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the  aim of this study was to evaluate the effects of vitamin D supplementation
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations
Kohsaka S, et al.
Nature Genetics, 46(6), 595-600 (2014)
Narasimhan P Agaram et al.
Genes, chromosomes & cancer, 53(9), 779-787 (2014-05-16)
Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS (ERMS). Although sclerosing and spindle cell RMS share clinical and morphologic features, a pathogenetic link based on shared
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