S9564

Amyloid Precursor Protein α, Secreted human

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

• Synonim(y): sAPPα
• Numer MDL: MFCD03454663
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in E. coli (N-terminal histidine tagged)
• Poziom jakości: 200
• Próba: >90% (SDS-PAGE)
• Formularz: buffered aqueous solution
• masa cząsteczkowa: ~100 kDa by SDS-PAGE
• numer dostępu UniProt: P05067
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... APP(351)

Opis

Opis ogólny

The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3.[1] It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.[2]

Zastosowanie

Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).[3][4][5]

Działania biochem./fizjol.

Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.[6]

Postać fizyczna

Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.

Uwaga dotycząca przygotowania

Expressed as a soluble protein and purified under non-denaturing conditions.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable