P0440

Pimaricin preparation

~2.5% (γ-irradiated Pimaricin), aqueous suspension

• Synonim(y): Pimaricin, Tennecetin, Natamycin preparation
• Wzór empiryczny (zapis Hilla): C₃₃H₄₇NO₁₃
• Numer CAS: 7681-93-8
• Masa cząsteczkowa: 665.73
• Beilstein: 1614878
• Numer MDL: MFCD00135085
• Kod UNSPSC: 51102829
• Identyfikator substancji w PubChem: 24898105
• NACRES: NA.85

Właściwości

• Postać: aqueous suspension
• stężenie: ~2.5% (γ-irradiated Pimaricin)
• rozpuszczalność: DMSO: soluble
• gęstość: 1.0 g/mL at 20 °C (lit.)
• spektrum działania antybiotyku: fungi; yeast
• Tryb działania: cell membrane | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C[C@@H](C)OC(=O)\C=C\[C@@]4([H])O[C@]4([H])C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
• InChI: 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
• Klucz InChI: NCXMLFZGDNKEPB-FFPOYIOWSA-N

Opis

Opis ogólny

This product is a saline suspension with approximately 2.5% pimaricin γ-irradiated.

Pimaricin is a polyene antifungal antibiotic produced by Streptomyces natalensis from soil near Pietermaritzburg, South Africa.¹ Pimaricin has antimicrobial activity similar to that of nystatin. In addition, it is active against Trichomonas vaginalis. Pimaricin is used in the treatment of candidiasis, trichomoniasis, fungal keratitis and aspergillosis. It has also been used as a food additive in some countries. In some studies, it has been shown to decrease the amount of mold upon which the Dermatophagoides pteronyssinus (house-dust mite) is dependent.²

Zastosowanie

Pimaricin is an amphoteric antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis and as a fungicide in agar media.

Działania biochem./fizjol.

An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nystatin and filipin, pimaricin does not change the permeability of the plasma membrane.

Uwaga dotycząca przygotowania

The product can be further diluted with 0.5 M sodium chloride giving a suspension as well. The product can also be further diluted into an organic solvent such as dimethylformamide (may also be soluble in DMSO).

The product and any aqueous dilutions will be suspensions and should not be sterile filtered.

Przechowywanie i stabilność

The product is not degraded by a single freeze-thaw cycle. The diluted product should be aliquoted and stored frozen.

Inne uwagi

20ml

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Light Sensitive

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves