The molarity of a 25 mg/ml solution is 0.052 M, which is equivalent to 52 mM. This calculation is based on a substance with a molar mass of 475.62 g/mol, where a 1 M solution is prepared by dissolving 475.62 g in 1 liter.
M8699
(R)-MG132
≥98%, Proteasome inhibitor
(R)-MG132
Synonim(y):
Z-L-Leu-D-Leu-L-Leu-al
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Wybierz wielkość
1 MG
1210,00 zł
1210,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C26H41N3O5
Numer CAS:
Masa cząsteczkowa:
475.62
UNSPSC Code:
12352200
NACRES:
NA.32
Przejdź do
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
(R)-MG132,
InChI
1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChI key
TZYWCYJVHRLUCT-VABKMULXSA-N
SMILES string
CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
assay
≥98%
solubility
DMSO or DMF: 25 mg/mL
storage temp.
−20°C
Quality Level
Powiązane kategorie
1 of 4
Ta pozycja | |||
|---|---|---|---|
| assay ≥98% | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥85% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO or DMF: 25 mg/mL | solubility DMSO: soluble | solubility H2O: 50 mg/mL | solubility H2O: 50 mg/mL |
Application
(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.
Biochem/physiol Actions
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.
Physical form
crystalline solid or supercooled liquid
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the molarity of a solution with a concentration of 25 mg/ml in DMSO?
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Which cells are utilized to assess the bioactivity of Product No. M8699, also known as (R)-MG132?
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The biological activity of product No. M8699, (R)-MG132 was measured using J558L multiple myeloma cells and EMT6 breast cancer cells.
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