H7041

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• Synonim(y): Interleukin-2, T-cell growth factor
• UNSPSC Code: 12352202
• NACRES: NA.77
• MDL number: MFCD00165721
• Biological source: human
• Recombinant: expressed in HEK 293 cells
• Form: lyophilized powder
• Mol wt: monomer 15 kDa (glycosylated)

Właściwości

• Nazwa produktu: Interleukin-2 human, IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested
• biological source: human
• Quality Segment: 100
• recombinant: expressed in HEK 293 cells
• form: lyophilized powder
• potency: ≤5.0 ng/mL ED₅₀
• quality: endotoxin tested
• mol wt: monomer 15 kDa (glycosylated)
• packaging: pkg of 5X10 μg, pkg of 10 μg, pkg of 100 μg
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P60568
• storage temp.: −20°C
• Gene Information: human ... IL2(3558)

Opis

General description

Recombinant human Interleukin‑2 (IL‑2) is an α‑helical cytokine expressed in HEK 293 cells and supplied as a glycosylated lyophilized protein. IL‑2 is commonly used in mammalian cell culture research involving immune‑related cell models.

Application

Recombinant IL‑2 has been used to culture peripheral blood mononuclear cells (PBMCs), activate immune effector cells, and support antibody‑dependent cellular assays in vitro.

Biochem/physiol Actions

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Interleukin‑2 (IL‑2) is an immunomodulatory cytokine that supports growth and maintenance of activated T cells, natural killer cells, and related immune cell populations in in vitro cell culture systems. IL-2 mediates the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. It is involved in the formation and essential functions of regulatory T cells. IL-2 is associated with apoptosis and thus, possesses antitumor response.

Preparation Note

Human Interleukin-2 (IL-2) expressed in human HEK 293 cells is a glycosylated monomer with a molecular mass of 15 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Analysis Note

The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable