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Merck

C7268

Chymostatin

powder

Synonim(y):

N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)

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Informacje o tej pozycji

Numer CAS:
9076-44-2
UNSPSC Code:
12352202
PubChem Substance ID:
329775144
NACRES:
NA.77
MDL number:
MFCD00071059

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Nazwa produktu

Chymostatin, microbial

SMILES string

OC(C(NC(NC(C1NC(NCC1)=N)C([F,Cl,Br,I]C)=O)=O)CC2=CC=CC=C2)=O

InChI key

MRXDGVXSWIXTQL-HYHFHBMOSA-N

biological source

microbial

form

powder

solubility

DMSO: 10 mM (Stock solutions stable for months at −20 °C.)

storage temp.

−20°C

Quality Level

300

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Ta pozycja
23079011004638001T4376
Chymostatin microbial

Sigma-Aldrich

C7268

Chymostatin

Chymostatin Contains chymostatin "A" as a major form.

Sigma-Aldrich

230790

Chymostatin

Chymostatin

Roche

11004638001

Chymostatin

N-p-Tosyl-L-phenylalanine chloromethyl ketone ≥97% (TLC), powder

Sigma-Aldrich

T4376

N-p-Tosyl-L-phenylalanine chloromethyl ketone

biological source

microbial

biological source

-

biological source

-

biological source

synthetic

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

200

form

powder

form

powder, solid

form

powder

form

powder

solubility

DMSO: 10 mM (Stock solutions stable for months at −20 °C.)

solubility

5% glacial acetic acid: 10 mg/mL, DMSO: 20 mg/mL

solubility

acetic acid: soluble 20 mg/mL

solubility

DMSO: >10 mg/mL (stable for several months at 4°C.), ethanol: 20 mg/mL

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Application

Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drug development.

Biochem/physiol Actions

Chymostatin is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, B, H, and L. It weakly inhibits human leucocyte elastase. It is effective at a final concentration of 100 to 200 μg/ml (10 to 100 μM). Chymostatin is often included in protease inhibitor cocktails used with plant extracts.
Inhibits the lysosomal proteinase cathepsin B, and the soluble Ca2+-activated proteinase.[1] Many young plant tissues express a chomostatin-sensitive serine protease.[2]

Preparation Note

Solubility testing in glacial acetic acid at 10 mg/ml yields a clear solution, which is usually colorless, but can be yellow in appearance. It is reportedly also soluble in DMSO; only slightly soluble in water and short-chain alcohols; insoluble in ethyl acetate, butyl acetate, ether, hexane, and petroleum ether. Stock solutions (10 mM) can be prepared in DMSO and are stable for months at -20 °C. Stock solutions can also be made in 0.1 M HCl. Dilute solutions (10-100 μM) are only stable for several hours, due to oxidation of the terminal aldehyde.

Other Notes

A mixture of A (major), B and C components. A: X=Leu; B: X=Val; C: X=Ile
chymostatin A MW = 607.7
chymostatin B MW = 593.7
chymostatin C MW = 607.7
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Klasa składowania

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000543027
0000521716
0000521716
0000528099
0000528099

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Qiuchen Guo et al.
Blood advances, 6(20), 5668-5675 (2022-04-29)
Programmed death ligand 1 (PD-L1) is an immune checkpoint protein that suppresses cytotoxic T lymphocytes and is often overexpressed in cancers. Due to favorable clinical trial results, immune checkpoint inhibition (ICI) is part of Food and Drug Administration approved immuno-oncology
Tina Birk et al.
BMC microbiology, 12, 174-174 (2012-08-15)
During the transmission route from poultry to the human host, the major foodborne pathogen C. jejuni may experience many types of stresses, including low pH caused by different acids. However, not all strains are equally sensitive to the stresses. The
H C Prosser et al.
Peptides, 31(8), 1540-1545 (2010-05-25)
ProAngiotensin-12 (PA12) is the most recent peptide to be identified as a functional component of the renin-angiotensin system (RAS). PA12 is reported to constrict rat coronary arteries and the aorta, dependent upon angiotensin II-converting enzyme 1 (ACE1) and chymase. The
D Messdaghi et al.
Biochimica et biophysica acta, 1480(1-2), 107-116 (2000-07-19)
Intercellular washing fluids from leaves of all tested higher plant species contained a serine-type protease which efficiently cleaved the artificial fluorogenic substrate MCA-Pro-Leu-Gly-Leu-Dnp-Ala-Arg (MCA). The activity varied between the species. The classification as serine protease was based on the sensitivity
Miaojuan Qiu et al.
Lipids in health and disease, 17(1), 183-183 (2018-08-02)
Lipotoxicity plays an important role in the pathogenesis of kidney injury. Our previous study demonstrated that activation of local renin-angiotensin system (RAS) was involved in saturated free fatty acids palmitic acid (PA)-induced tubular cell injuries. The current study aims to
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