C6427

Clindamycin 2-phosphate

Name: Clindamycin 2-phosphate
Brand: SIGMA
Price: 1000 PLN

aminoglycoside antibiotic

Synonim(y):

Clindamycin 2-dihydrogen phosphate

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50 MG

1000,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₈H₃₄ClN₂O₈PS

Numer CAS:

24729-96-2

Masa cząsteczkowa:

504.96

NACRES:

NA.76

PubChem Substance ID:

24892866

UNSPSC Code:

51102829

EC Number:

246-433-0

MDL number:

MFCD07793328

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Quality Level

100

form

solid

solubility

DMSO: 224 mg/mL at 25 °C

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1

InChI key

UFUVLHLTWXBHGZ-MWBQRTRKSA-N

Powiązane kategorie

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

Phosphates

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Ta pozycja	C5269	L6004	62143
Sigma-Aldrich C6427 Clindamycin 2-phosphate	Sigma-Aldrich C5269 Clindamycin hydrochloride	Sigma-Aldrich L6004 Lincomycin hydrochloride	Sigma-Aldrich 62143 Lincomycin hydrochloride
mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes
antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
form solid	form powder or crystals	form -	form powder or crystals
solubility DMSO: 224 mg/mL at 25 °C	solubility H₂O: 50 mg/mL	solubility H₂O: soluble 50 mg/mL	solubility H₂O: 50 mg/mL, clear, colorless to faintly yellow
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

Chemical structure: macrolide

Application

Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines [1], Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase [2].

Biochem/physiol Actions

Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. [2]. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.

Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.

Other Notes

Antibacterial and antiprotozoal antibiotic of the licosamide class.

Keep container tightly closed in a dry and well-ventilated place.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H317,H319,H362

pcodes

P260 - P263 - P280 - P301 + P312 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number

107H1159V

107H1159

047F07202

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.

Zhiyong Liao et al.

Molecular pharmacology, 70(1), 366-372 (2006-04-19)

DNA topoisomerase I (Top1) is the target of camptothecin, and novel Top1 inhibitors are in development as anticancer agents. Top1 inhibitors damage DNA by trapping covalent complexes between the Top1 catalytic tyrosine and the 3'-end of the broken DNA. Tyrosyl-DNA

Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris.

L Babayeva et al.

Journal of the European Academy of Dermatology and Venereology : JEADV, 25(3), 328-333 (2010-07-30)

No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties. To

Assemblage of drug release modules: effect of module shape and position in the assembled systems on floating behavior and release rate.

C Hascicek et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 116-121 (2010-11-23)

The aim of this work was to study the clindamycin release kinetics from floating delivery systems consisting of two modules assembled in void configuration, according to the modified release technology platform known as Dome Matrix®. Two modules differently shaped, i.e.

Separation and characterization of clindamycin phosphate and related impurities in injection by liquid chromatography/electrospray ionization mass spectrometry.

Shao-Min Wang et al.

Rapid communications in mass spectrometry : RCM, 23(6), 899-906 (2009-02-18)

A simple high-performance liquid chromatography/electrospray ionization tandem mass spectrometric (HPLC/ESI-MS/MS) method has been developed for the rapid identification of clindamycin phosphate and its degradation products or related impurities in clindamycin phosphate injection. Detection was performed by quadrupole time-of-flight mass spectrometry

Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate).

Marija Vukomanović et al.

Colloids and surfaces. B, Biointerfaces, 82(2), 414-421 (2010-10-19)

The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
C6427-100MG	04061833511206
C6427-50MG	04061833511213

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