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Merck

A8003

Allopurinol

synthetic (organic), ≥99% (TLC), xanthine oxidase inhibitor, powder

Synonim(y):

1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxypyrazolo(3,4-d)pyrimidine, 4-Hydroxypyrazolo[3,4-d]pyrimidine, HPP

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5 G

751,00 zł

25 G

1270,00 zł

751,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C5H4N4O
Numer CAS:
315-30-0
Masa cząsteczkowa:
136.11
NACRES:
NA.77
PubChem Substance ID:
24278141
UNSPSC Code:
12352202
EC Number:
206-250-9
MDL number:
MFCD00599413

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Nazwa produktu

Allopurinol, xanthine oxidase inhibitor

SMILES string

O=C1NC=Nc2[nH]ncc12

InChI key

OFCNXPDARWKPPY-UHFFFAOYSA-N

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

biological source

synthetic (organic)

assay

≥99% (TLC)

form

powder

mp

>300 °C (lit.)

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

Gene Information

human ... XDH(7498)

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Pokaż różnice

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Ta pozycja
PHR13771013002A0350000
Allopurinol xanthine oxidase inhibitor

Sigma-Aldrich

A8003

Allopurinol

Allopurinol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1377

Allopurinol

Allopurinol United States Pharmacopeia (USP) Reference Standard

USP

1013002

Allopurinol

Allopurinol European Pharmacopoeia (EP) Reference Standard

A0350000

Allopurinol

assay

≥99% (TLC)

assay

-

assay

-

assay

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Gene Information

human ... XDH(7498)

Gene Information

human ... XDH(7498)

Gene Information

human ... XDH(7498)

Gene Information

human ... XDH(7498)

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

form

powder

form

-

form

-

form

-

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

-

solubility

-

solubility

-

Application

Allopurinol has been used:
  • to decrease the uric acid levels and study its effect on renal injury and inflammation in mice[1]
  • as a xanthine oxidase inhibitor to test panton-valentine leukocidin (PVL) neutrophil extracellular traps (NETosis) dependence on different enzymes, channels, or organelles using human polymorphonuclear cells (hPMNs)[2]
  • as a reference standard to study the inhibitory effect of olive leaf components on xanthine oxidase in vitro[3]

Allopurinol is suitable for:
  • intravenous injection in mice for inhibition of xanthine oxidase[4][5]
  • use as an inhibitor of xanthine oxidase[6]
  • use as a positive control in xanthine oxidase inhibition assay[7]
  • use in the preparation of University of Wisconsin solution for osmotic stabilization to enhance the density differences between islets and acinar fragments during porcine islet purification[8]

Biochem/physiol Actions

Allopurinol is a purine analog that inhibits certain enzymes involved in purine metabolism.[3] It is known to reduce the synthesis of uric acid in the body. Allopurinol mediated inhibition of xanthine oxidase exhibits anti-inflammatory effects on atherosclerosis, acute lung injury, and congestive heart failure.[1]
Inhibitor of xanthine oxidase and de novo pyrimidine biosynthesis. A classical agent in treatment of hyperuricemia and gout.
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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certyfikaty analizy (CoA)

Lot/Batch Number
MKCX5681
MKCV7617
MKCW5113
MKCV0752
MKCS5502

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

H Kubo et al.
The Journal of clinical investigation, 97(11), 2680-2684 (1996-06-01)
Mice with chronic granulomatous disease (X-CGD mice) generated by mutating the X-linked gene for a subunit of NADPH oxidase have been analyzed for their ability to respond to intravenous injection of purified cobra venom factor (CVF). This agent in wild-type
Andreas Haryono et al.
The Kobe journal of medical sciences, 64(3), E107-E114 (2019-01-23)
Hyperuricemia contributed to endothelial dysfunction, activation of the RAS system, increased oxidative stress and maladaptive immune system response. M1 and M2 macrophages were known to contribute to the onset of renal fibrosis. This study aimed to look at the effect
Nitrate partially inhibits lipopolysaccharide-induced inflammation by maintaining mitochondrial function.
Yang Yang et al.
The Journal of international medical research, 48(2), 300060520902605-300060520902605 (2020-02-12)
Michael P M van der Burg et al.
TheScientificWorldJournal, 3, 1154-1159 (2003-12-04)
Generally, prior to the purification of isolated pancreatic islets, the collagenase-digested tissue is incubated in the University of Wisconsin solution (UWS; approximately 320 mOsm) for osmotic stabilization to preserve or improve the density differences between islets and acinar fragments. The
R Chavez-Cartaya et al.
Transplant international : official journal of the European Society for Organ Transplantation, 12(3), 213-221 (1999-08-03)
Free radical scavengers have been utilized to prevent the consequences of ischemia, however, results do not seem conclusive. In our study we analyzed the blood flow, function, and histology of rat liver tissue after warm liver ischemia, in order to
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Produkty

Critical Inhibitor Characteristics to Consider

Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.

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