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Merck

A5960

Sigma-Aldrich

L-Ascorbic acid

BioXtra, ≥99.0%, crystalline

Synonim(y):

L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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10 MG
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25 G
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100 G
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500 G
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10 MG
132,00 zł
25 G
336,00 zł
100 G
1110,00 zł
500 G
3100,00 zł

About This Item

Wzór empiryczny (zapis Hilla):
C6H8O6
Numer CAS:
Masa cząsteczkowa:
176.12
Beilstein:
84272
Numer WE:
Numer MDL:
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
NACRES:
NA.26

132,00 zł


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linia produktu

BioXtra

Poziom jakości

Próba

≥99.0%

Formularz

crystalline

metody

cell culture | mammalian: suitable

zanieczyszczenia

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

pozostałość po prażeniu

≤0.1%

kolor

white to off-white

pH

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

rozpuszczalność

H2O: 0.5 M, clear, colorless

ślady anionów

sulfate (SO42-): ≤0.05%

ślady kationów

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

ciąg SMILES

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

Klucz InChI

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

informacje o genach

human ... SLC23A2(9962)

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Opis ogólny

Ascorbic acid is also referred to as Vitamin C.[1] It contains a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Vitamin C is a water-soluble vitamin.[2] Vitamin C is a part of citrus fruits, such as Indian gooseberry, broccoli, strawberries, brussels sprouts.[2] L-ascorbic acid is the biologically active form of ascorbic acid. It is unstable and hydrophilic.[1] Ascorbic acid carries a neutral charge, which gets converted to ascorbate by protonation.[3]

Zastosowanie

  • L-Ascorbic acid has been used to induce osteoblast differentiation from primary bone marrow cultures.[4]
  • It has been used for the differentiation of hCMPCs (human cardiomyocyte progenitor cells) into cardiomyocytes.[5]
  • It has been used to measure the mitochondrial electron transport chain (complex IV) activity.[6]

Działania biochem./fizjol.

L-Ascorbic acid plays a role in production of neurotransmitters, carnitine and collagen synthesis.[2] Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.[7] Vitamin C exhibits anti-oxidant properties. Vitamin C is implicated in conferring protection against photoaging and anti-aging.[1] Deficiency of vitamin C is associated with scurvy, bleeding gums, poor wound healing, anemia and muscle degeneration.[2]

Przestroga

May darken in storage.
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produkt powiązany

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Padayatty SJ et al.
Journal of the American College of Nutrition, 22, 18-18 (2003)
Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus.
Doherty E et al.
Antioxidants & Redox Signaling, 21, 56-56 (2014)
CCN3 impairs osteoblast and stimulates osteoclast differentiation to favor breast cancer metastasis to bone.
Ouellet V et al.
The American Journal of Pathology, 178, 2377-2377 (2011)
Vitamin C in health and disease: its role in the metabolism of cells and redox state in the brain
Figueroa M R and Rivas A S
Frontiers in Physiology, 6(4), 397-397 (2015)
Topical vitamin C and the skin: mechanisms of action and clinical applications
Al-Niaimi F and Chiang N Y Z
The Journal of Clinical and Aesthetic Dermatology, 10(7), 14-14 (2017)

Produkty

Single molecule electronics is the endeavour of constructing electronic circuitry with single molecules as the fundamental building block.

Questions

1–7 of 7 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is L-ascorbic acid, Product A5960, the same as vitamin C?

    1 answer
    1. Yes, L-ascorbic acid is a synonym for vitamin C.

      Helpful?

  4. What is the extinction coefficient of L-ascorbic acid, Product A5960?

    1 answer
    1. According to the Data for Biochemical Research, 3rd ed., Dawson, R. M. C., et al., Oxford University Press (New York, NY 1986), p. 116, the L-ascorbic acid extinction coefficient: EmM = 7.0 (265 nm, water), 7.5 (245 nm, acid).

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  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  6. What is the pKa of L-ascorbic acid, Product A5960?

    1 answer
    1. The pKa values for L-ascorbic acid (from the chemicals encyclopedia published by the Royal Society of Chemistry) are 4.17 and 11.57.

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  7. What is the solution stability of L-ascorbic acid, Product A5960?

    1 answer
    1. Aqueous solutions are stable only in the absence of oxygen.  Aqueous solutions are most stable at pH 5-6, very unstable at alkaline pH. (Data for Biochemical Research, 3rd ed., Dawson, R. M. C., et al., Oxford University Press (New York, NY: 1986), p. 116)  Degradation is markedly increased in the presence of transition metal ions, especially Cu(II) and Fe(III).  The first stage of oxidation of L-ascorbic acid to dehydroascorbic acid is reversible and the biological activity is retained.  Further oxidation to 2,3-diketogulonic acid is not reversible and the activity is lost. (Omura, H., and Yamafuji, K., in Methodicum Chimicum, 11(2), Korte, F., and Goto, M., eds., Academic Press (New York, NY: 1977), p. 115).

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