434R-1
ERG (EP111) Rabbit Monoclonal Primary Antibody
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Produkt 434R-1 nie jest obecnie dostępny w sprzedaży w Twoim kraju Skontaktuj się z zespołem ds. pomocy technicznej
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
100
500
białko sprzężone
unconjugated
forma przeciwciała
culture supernatant
rodzaj przeciwciała
primary antibodies
klon
EP111, monoclonal
opis
(For In Vitro Diagnostic Use in Select Regions (See Chart))
Formularz
buffered aqueous solution
reaktywność gatunkowa
human
opakowanie
vial of 0.1 mL concentrate (434R-14)
vial of 0.5 mL concentrate (434R-15)
bottle of 1.0 mL predilute (434R-17)
vial of 1.0 mL concentrate (434R-16)
bottle of 7.0 mL predilute (434R-18)
producent / nazwa handlowa
Cell Marque®
metody
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
izotyp
IgG
kontrola
tonsil
Warunki transportu
wet ice
temp. przechowywania
2-8°C
wizualizacja
nuclear
informacje o genach
human ... ERG(2078)
Opis ogólny
ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.1 ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.1 ERG has also been observed to be positive in a minority of Ewing sarcomas.2 This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).5 ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.1
Jakość
 IVD |  IVD |  IVD |  RUO |
Powiązanie
ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Postać fizyczna
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Uwaga dotycząca przygotowania
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Inne uwagi
For Technical Service please contact: 800-665-7284 or email: [email protected]
Informacje prawne
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Jason L Hornick
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27 Suppl 1, S47-S63 (2014-01-05)
Immunohistochemistry plays a key role in the diagnosis of soft tissue tumors. Until recently, however, the primary purpose of immunohistochemistry in this context was simply to attempt to demonstrate a line of differentiation. Unfortunately, most traditional markers (predominantly directed against
J R Bänffer et al.
Antonie van Leeuwenhoek, 53(3), 183-190 (1987-01-01)
The immune response was studied in 238 human patients with Campylobacter jejuni/coli (CJC)-infections in Rotterdam by the counterimmunoelectrophoresis (CIE) test, a commercial complement fixation test (CFT) and the passive haemagglutination test (HA). Antibodies became detectable in the three tests around
Oksana Yaskiv et al.
American journal of clinical pathology, 138(6), 803-810 (2012-11-20)
Avian v-ets erythroblastosis virus E26 oncogene homolog (ERG) is highly sensitive and specific for endothelial neoplasms and specific for prostate carcinoma. We characterized a rabbit anti-ERG antibody as an immunohistochemical agent to detect ERG expression in various tumors using tissue
Markku Miettinen et al.
The American journal of surgical pathology, 35(3), 432-441 (2011-02-15)
ERG, an ETS family transcription factor, is known to be expressed in endothelial cells, and oncogenic ERG gene fusions occur in subsets of prostatic carcinoma, acute myeloid leukemia, and Ewing sarcoma. In this study, we immunohistochemically investigated nuclear ERG expression
Sarah Minner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(1), 106-116 (2012-08-18)
Approximately 50% of prostate cancers are characterized by TMPRSS2 (transmembrane protease serine 2)-ERG (avian v-ets erythroblastosis virus E26 oncogene homolog) gene fusions resulting in an androgen-regulated overexpression of the transcription factor ERG. Some studies have suggested prognostic or predictive relevance
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