ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
Synonyms:
erg-3, p55
Species:
Human ERG (2078), Mouse Erg (13876), Rat Erg (170909), chicken ERG (374146), Zebrafish erg (494073), Horse ERG (100051563), domestic cat ERG (101099895), dog ERG (487760), cow ERG (535231), Domestic Rabbit ERG (100347277) ...More
UniProtKB ID:
Gene ID:
- Human(2078) Summary: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012]
- Mouse(13876) avian erythroblastosis virus E-26 (v-ets) oncogene related
- Rat(170909) v-ets avian erythroblastosis virus E26 oncogene
- chicken(374146) v-ets erythroblastosis virus E26 oncogene homolog
- Zebrafish(494073) v-ets erythroblastosis virus E26 oncogene like (avian)
- Horse(100051563) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- domestic cat(101099895) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- dog(487760) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- cow(535231) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- Domestic Rabbit(100347277) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- sheep(101110646) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- naked mole-rat(101717041) v-ets erythroblastosis virus E26 oncogene homolog (avian)
- domestic guinea pig(100713723) v-ets erythroblastosis virus E26 oncogene homolog (avian)
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Antibodies
Product Number
Description
Species Reactivity
Application
ERG (EP111) Rabbit Monoclonal Primary Antibody, ,
Species Reactivity
human
Application
immunohistochemistry
Anti-ERG antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-ERG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-ERG antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
western blot