CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach. Data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) making it a useful marker for this type of tumor.
379M-1
Carbonic Anhydrase IX (CA IX) (MRQ-54) Mouse Monoclonal Antibody
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Produkt 379M-1 nie jest obecnie dostępny w sprzedaży w Twoim kraju Skontaktuj się z zespołem ds. pomocy technicznej
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
100
500
białko sprzężone
unconjugated
forma przeciwciała
culture supernatant
rodzaj przeciwciała
primary antibodies
klon
MRQ-54, monoclonal
opis
For In Vitro Diagnostic Use in Select Regions (See Chart)
Formularz
buffered aqueous solution
reaktywność gatunkowa
human
opakowanie
vial of 0.1 mL concentrate (379M-14)
vial of 0.5 mL concentrate (379M-15)
bottle of 1.0 mL predilute (379M-17)
vial of 1.0 mL concentrate (379M-16)
bottle of 7.0 mL predilute (379M-18)
producent / nazwa handlowa
Cell Marque®
metody
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
izotyp
IgG2b
kontrola
clear cell renal cell carcinoma, gallbladder epithelium
Warunki transportu
wet ice
temp. przechowywania
2-8°C
wizualizacja
membranous
informacje o genach
human ... CA9(768)
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Opis ogólny
CA IX are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO2. Among these, CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder[1]. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme[1][2][3][4]. CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors5. Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC); it has sensitivity of 85% to 100% for clear cell RCC and this imparts diagnostic utility. Anti-CA IX may also play a role in distinguishing clear cell RCC from chromophobe RCC. Anti-CA IX, together with antibodies against Pax 2, Ksp-cadherin, and CD117, forms a robust panel that can be used to make this distinction. Strong diffuseto-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC6.
Jakość
 IVD |  NA |  NA |  NA |
Powiązanie
Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Postać fizyczna
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Uwaga dotycząca przygotowania
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Inne uwagi
For Technical Service please contact: 800-665-7284 or email: [email protected]
Informacje prawne
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Certyfikaty analizy (CoA)
Lot/Batch Number
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Hikmat A Al-Ahmadie et al.
The American journal of surgical pathology, 32(3), 377-382 (2008-02-28)
Carbonic anhydrase IX (CAIX)-a protein maintaining intracellular and extracellular pH-reportedly also influences regulation of cell proliferation, oncogenesis, and tumor progression. Its expression is von Hippel-Lindau-hypoxia inducible factor pathway dependent. Immunohistochemical (IHC) studies show that CAIX is diffusely overexpressed in clear
Thambi Dorai et al.
Cancer investigation, 24(8), 754-779 (2006-12-13)
Renal cell carcinoma (RCC) has the highest rate of occurrence within the US when compared with other countries. Recent advances in the basic research and molecular diagnostics of this malignancy have revealed that RCC is not a single disease, but
S Ivanov et al.
The American journal of pathology, 158(3), 905-919 (2001-03-10)
An acidic extracellular pH is a fundamental property of the malignant phenotype. In von Hippel-Lindau (VHL)-defective tumors the cell surface transmembrane carbonic anhydrase (CA) CA9 and CA12 genes are overexpressed because of the absence of pVHL. We hypothesized that these
Mari Leppilampi et al.
World journal of gastroenterology, 9(7), 1398-1403 (2003-07-11)
To systematically study the expression of carbonic anhydrase (CA) isozymes IX and XII in gastric tumors. We analyzed a representative series of specimens from non-neoplastic gastric mucosa and from various dysplastic and neoplastic gastric lesions for the expression of CA
A J Kivelä et al.
Histochemistry and cell biology, 114(3), 197-204 (2000-11-18)
Carbonic anhydrase (CA) IX and XII are transmembrane isoenzymes which are expressed in several epithelia and overexpressed in some carcinomas. They have recently been linked to von Hippel-Lindau gene-mediated carcinogenesis in that both isoenzymes are downregulated by the product of
Powiązane treści
Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.
Przegląd immunohistochemii diagnostycznej podkreśla jej znaczenie w diagnostyce nowotworów i wykrywaniu chorób zakaźnych we współczesnej patologii klinicznej.
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Where is the immunogen for the antibody located - ECD or not? (Ref#379M-14)
1 answer-
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