CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach. Data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) making it a useful marker for this type of tumor.
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379M-1
Carbonic Anhydrase IX (CA IX) (MRQ-54) Mouse Monoclonal Antibody
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Informacje o tej pozycji
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
MRQ-54, monoclonal
Application:
IHC (p)
Citations:
6
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Pozwól nam pomócbiological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
MRQ-54, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (379M-14), vial of 0.5 mL concentrate (379M-15), bottle of 1.0 mL predilute (379M-17), vial of 1.0 mL concentrate (379M-16), bottle of 7.0 mL predilute (379M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
isotype
IgG2b
control
clear cell renal cell carcinoma, gallbladder epithelium
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
Gene Information
human ... CA9(768)
General description
CA IX are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO2. Among these, CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme. CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors5. Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC); it has sensitivity of 85% to 100% for clear cell RCC and this imparts diagnostic utility. Anti-CA IX may also play a role in distinguishing clear cell RCC from chromophobe RCC. Anti-CA IX, together with antibodies against Pax 2, Ksp-cadherin, and CD117, forms a robust panel that can be used to make this distinction. Strong diffuseto-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC6.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  NA |  NA |  NA |
Other Notes
Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Where is the immunogen for the antibody located - ECD or not? (Ref#379M-14)
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