229075

1,8-Dihydroxy-3-methylanthraquinone

98%

• Synonim(y): 3-Methylchrysazin, Chrysophanic acid
• Wzór empiryczny (zapis Hilla): C₁₅H₁₀O₄
• Numer CAS: 481-74-3
• Masa cząsteczkowa: 254.24
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 57648009
• EC Number: 207-572-2
• Beilstein/REAXYS Number: 1252300
• MDL number: MFCD00001208

Właściwości

• InChI key: LQGUBLBATBMXHT-UHFFFAOYSA-N
• InChI: 1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
• SMILES string: Cc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• assay: 98%
• form: crystalline
• color: yellow-orange
• solubility: chloroform: 1%
• antibiotic activity spectrum: neoplastics, viruses
• mode of action: enzyme | inhibits
• Quality Level: 100
• Gene Information: human ... ELA2(1991)

Opis

Application

Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells [1]. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro [2].

Biochem/physiol Actions

Anticancer activity for chrysophanic acid is via the EGFR/mTOR mediated signaling transduction pathway [1]. Chrysophanic acid has two hydrophobic positions on the molecule (C-6 and the methyl group attached to C-3) which are responsible for the compound′s activity against poliovirus [2].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves