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Y0000610

Cladribine impurity C

European Pharmacopoeia (EP) Reference Standard

Synonim(y):

2-Chloroadenine, 2-Chloro-6-aminopurine

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About This Item

Wzór empiryczny (zapis Hilla):
C5H4ClN5
Numer CAS:
1839-18-5
Masa cząsteczkowa:
169.57
Numer MDL:
MFCD00037925
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329831049
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

rodzina API

cladribine

producent / nazwa handlowa

EDQM

mp

384-389 °C

Zastosowanie

pharmaceutical (small molecule)

format

neat

Warunki transportu

wet ice

temp. przechowywania

−20°C

ciąg SMILES

Nc1nc(Cl)nc2nc[nH]c12

InChI

1S/C5H4ClN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)

Klucz InChI

HBJGQJWNMZDFKL-UHFFFAOYSA-N

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Cladribine impurity C EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.

Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H302

Zwroty wskazujące środki ostrożności

P264 - P270 - P301 + P312 + P330 - P501

Klasyfikacja zagrożeń

Acute Tox. 4 Oral

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Obsługa Klienta

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

P Hentosh et al.
Molecular pharmacology, 45(5), 955-961 (1994-05-01)
2'-Chloro-2'-deoxyadenosine triphosphate (cladribine), a purine nucleotide analog and potent antileukemic agent, was enzymatically incorporated into 98-base oligomers in place of dATP to investigate the molecular consequences of 2-chloroadenine (CIAde) in DNA. We have used the resultant oligomers as templates for
S A Taran et al.
Prikladnaia biokhimiia i mikrobiologiia, 44(2), 181-186 (2008-08-02)
Cladribine (2-chloro-2'-deoxyadenosine) was synthesized using intact cells of the recombinant Escherichia coli strain producing Geobacillus stearothermophilus B-2194 thermostable purine-nucleoside phosphorylase II (EC 2.4.2.1). Use of the cells containing this thermostable enzyme allowed the process to be conducted at a temperature
Kiran Kumar Akula et al.
Epilepsy research, 78(1), 60-70 (2007-12-07)
Multiple lines of investigations have explored the role of cyclooxygenases (COX) in epilepsy and related neuropsychiatric disorders. Cyclooxygenase particularly, COX-2 expression was found to increase in brain during seizure paradigms. The present study was carried out to investigate the effect
P Hentosh et al.
Analytical biochemistry, 201(2), 277-281 (1992-03-01)
By utilization of polymerase chain reaction techniques, single-stranded DNA of defined length and sequence containing a purine analog, 2-chloroadenine, in place of adenine was synthesized. This was accomplished by a combination of standard polymerase chain amplification reactions with Thermus aquaticus
F Bontemps et al.
Biochemical pharmacology, 59(10), 1237-1243 (2000-03-29)
EHEB cells, a continuous cell line derived from a patient with B cell chronic lymphocytic leukemia (B-CLL), synthesized, when incubated with tritiated 2-chloro-2'-deoxyadenosine (CdA), labeled mono-, di-, and triphosphate ribonucleosides at a much higher rate than CdA deoxyribonucleotides. Further analysis
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