PHR1265

Carvedilol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): Carvedilol, 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190
• Wzór empiryczny (zapis Hilla): C₂₄H₂₆N₂O₄
• Numer CAS: 72956-09-3
• Masa cząsteczkowa: 406.47
• Numer MDL: MFCD00864692
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329823261
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• agency: traceable to Ph. Eur. Y0001427; traceable to USP 1096622
• rodzina API: carvedilol
• Certyfikat analizy: current certificate can be downloaded
• metody: HPLC: suitable; gas chromatography (GC): suitable
• Zastosowanie: pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: 2-30°C
• ciąg SMILES: OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
• InChI: 1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
• Klucz InChI: OGHNVEJMJSYVRP-UHFFFAOYSA-N
• informacje o genach: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Opis

Opis ogólny

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Carvedilol is a lipophilic β₁- and β₂-adrenoreceptor antagonist that exhibits antioxidant and antiproliferative properties. It is prescribed as a medicine for the treatment of hypertension, stable angina pectoris, post myocardial infarction with left ventricular dysfunction and all degrees of symptomatic chronic heart failure.

Zastosowanie

Carvedilol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Działania biochem./fizjol.

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Przestroga

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAA9063 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS09
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H373,H411
• Zwroty wskazujące środki ostrożności: P260 - P273 - P314 - P391 - P501
• Klasyfikacja zagrożeń: Aquatic Chronic 2 - STOT RE 2
• Organy docelowe: Liver,spleen,Uterus (including cervix),Adrenal gland
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable