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Kluczowe dokumenty
A8456
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
≥97.0% (HPLC)
Synonim(y):
AEBSF
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25 MG
276,00 zł
100 MG
829,00 zł
500 MG
3170,00 zł
276,00 zł
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Wybierz wielkość
Zmień widok
25 MG
276,00 zł
100 MG
829,00 zł
500 MG
3170,00 zł
About This Item
Wzór empiryczny (zapis Hilla):
C8H10FNO2S · HCl
Numer CAS:
Masa cząsteczkowa:
239.69
Beilstein:
7604627
Numer MDL:
Kod UNSPSC:
12352202
Identyfikator substancji w PubChem:
NACRES:
NA.77
276,00 zł
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Poproś o zamówienie zbiorcze
Polecane produkty
pochodzenie biologiczne
synthetic (organic)
Poziom jakości
Próba
≥97.0% (HPLC)
Formularz
powder
mp
183-191 °C
rozpuszczalność
H2O: 50 mg/mL
temp. przechowywania
−20°C
ciąg SMILES
FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl
InChI
1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
Klucz InChI
WRDABNWSWOHGMS-UHFFFAOYSA-N
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Opis ogólny
stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.
Zastosowanie
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) has been used:
- as a protease inhibitor in plasma samples to prevent acylated ghrelin (AG) degradation
- as a snake venom serine proteinase (SVSP) inhibitor in SVSP inhibition or AEBSF assay to test the involvement of SVSPs on the fibrinogen-clotting activity
- as a component in NP-40 lysis buffer to resuspend cell pellets for preparing cell lysates
Recommended concentrations for use are 0.1-1 mM.
Działania biochem./fizjol.
AEBSF can inhibit acetylcholinesterase (AChE).
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) is an irreversible serine protease inhibitor. Inhibition constants are similar to those of phenylmethanesulfonyl fluoride (PMSF) and diisopropylfluorophosphate (DFP). AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein, and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water, and improved stability in aqueous solutions. AEBSF can be used in cell culture in concentrations of up to 0.25 mM.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Dam. 1 - Skin Corr. 1A
Kod klasy składowania
8A - Combustible corrosive hazardous materials
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Produkty
ReadyShield® phosphatase and protease inhibitor cocktail FAQ for sample protection in a variety of cell types and tissue extracts, including mammalian, plant, and microbial samples. Our ReadyShield® Protease Inhibitor Cocktail is a non-freezing solution that contains inhibitors with a broad specificity for serine, cysteine, acid proteases and aminopeptidases.
Enzym analityczny Chymotrypsyna: Chymotrypsyna jest wytwarzana w komórkach gruczołowych trzustki jako nieaktywny prekursor, chymotrypsynogen.
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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What is the Department of Transportation shipping information for this product?
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How stable is Product A8456, 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, in solution?
1 answer-
Solutions in water are slightly acidic and retain inhibitory activity for up to six months when stored refrigerated. Solutions at pHs above 7 are less stable. Stock solutions should be stored at a pH less than 7. If a final pH of greater than 7 is required, the pH adjustment should be done shortly before use.
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In what solvents is Product A8456, 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, soluble?
1 answer-
It is highly soluble in water and in DMSO, at 50 mg/mL (approximately 200 mM), yielding a clear colorless solution. AEBSF may be used in cell culture medium at concentrations up to 0.25 mM.
Helpful?
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What is the recommended working concentration for Product A8456, 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride?
1 answer-
Our recommended working concentration range is 0.1 mM to 1 mM; the optimal concentration will depend on the application.
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