AB5405
Anti-Opsin Antibody, Red/Green
Chemicon®, from rabbit
Synonim(y):
Anti-CBBM, Anti-CBP, Anti-COD5, Anti-RCP, Anti-ROP
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
forma przeciwciała
purified antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
reaktywność gatunkowa
mouse
producent / nazwa handlowa
Chemicon®
metody
immunohistochemistry: suitable (paraffin)
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... OPN1LW(5956)
Opis ogólny
Long-wave-sensitive opsin 1/Medium-wave-sensitive opsin 1 (UniProt: P04000/P04001; also known as Red cone photoreceptor pigment/Green cone photoreceptor pigment, Red-sensitive opsin/ Green-sensitive opsin, ROP/GOP) are encoded by the OPN1LW/OPN1MW (also known as RCP/GCP) genes (Gene ID: 5956/2652) in human. The full range of color discrimination in humans is based on the presence and function of three cone photoreceptors. Each cone type possesses a photo-sensitive pigment-protein complex consisting of 11-cis retinal and a unique opsin protein that gives sensitivity in the short (S cone, peak sensitivity about 420 nm), middle (M cone, peak sensitivity about 530 nm with polymorphism), and long (L cone, peak sensitivity about 560 nm with polymorphism) wavelengths of the light spectrum. Opsins are multi-pass membrane proteins that belongs to the G-protein coupled receptor 1 family. They consist of four extracellular, 7 helical, and four cytoplasmic domains. Genes for the three types of cone opsins and the rod photoreceptor rhodopsin gene seem to be homologous with varying amounts of conservation. Strongest conservation is between the middle (green) and long (red) wavelength sensitive pigments on the X chromosome, suggesting a relatively recent duplication/divergence event. The S cone (blue) opsin seems to have a stronger conservation with rhodopsin. Cone photoreceptor distribution in humans is dominated by the M and L cone pigments. Mutations in OPN1MW and OPN1LW genes are known to cause color blindness that is characterized by a dichromasy in which red and green are confused, without loss of luminance or shift or shortening of the spectrum. Some mutations also lead to cone dystrophy leading to progressive degeneration of the cone photoreceptor with some preservation of rod function. (Ref.: Neitz, M., and Neitz, J. (2000). Arch. Ophthalmol. 118(5); 691-700).
Specyficzność
Mouse. Reactivity with other species has not been determined
This rabbit polyclonal antibody detects Red-sensitive opsin/ Green-sensitive opsins.
Immunogen
Full-length, recombinant human red/green opsin.
Recombinant human red/green opsin.
Zastosowanie
Anti-Opsin Red/Green, Cat. No. AB5405, is a rabbit polyclonal antibody that detects Opsin Red/Green and is tested for use in Immunohistochemistry (Paraffin).
Jakość
Evaluated by Immunohistochemistry (Paraffin) in Mouse retina tissue sections.Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected Opsin Red/Green in Mouse retina tissue sections.
Postać fizyczna
Format: Purified
Purified rabbit polyclonal antibody in buffer containing 0.02 M phosphate buffer, pH 7.6, 0.25 M NaCl, and 0.1% sodium azide.
Przechowywanie i stabilność
Recommended storage: +2°C to +8°C.
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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polecane
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Gene therapy for red-green colour blindness in adult primates.
Mancuso, K; Hauswirth, WW; Li, Q; Connor, TB; Kuchenbecker, JA; Mauck, MC; Neitz, J; Neitz, M
Nature null
Xue Cai et al.
Experimental eye research, 140, 130-138 (2015-09-02)
Mutation of the Tub gene results in the mislocalization of photoreceptor-specific proteins and eventually retinal degeneration. However, the exact mechanism underlying the retinal degeneration remains largely unknown. In this study, we discovered that the expression of endoplasmic reticulum (ER) stress
E R Ritchey et al.
Neuroscience, 169(3), 1376-1391 (2010-06-12)
Guanine nucleotide-binding protein beta3 (GNB3) is an isoform of the beta subunit of the heterotrimeric G protein second messenger complex that is commonly associated with transmembrane receptors. The presence of GNB3 in photoreceptors, and possibly bipolar cells, has been confirmed
Tatyana Appelbaum et al.
Molecular vision, 22, 319-331 (2016-04-29)
Canine X-linked progressive retinal atrophy 1 (XLPRA1) caused by a mutation in retinitis pigmentosa (RP) GTPase regulator (RPGR) exon ORF15 showed significant variability in disease onset in a colony of dogs that all inherited the same mutant X chromosome. Defective
Meriam Boubakri et al.
The Journal of biological chemistry, 291(47), 24465-24474 (2016-09-30)
In the retina, aberrant opsin transport from cell bodies to outer segments leads to retinal degenerative diseases such as retinitis pigmentosa. Opsin transport is facilitated by the intraflagellar transport (IFT) system that mediates the bidirectional movement of proteins within cilia.
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