AB2261
Anti-Tbr1 Antibody
from chicken, purified by affinity chromatography
Synonim(y):
T-box, brain, 1
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
chicken
Poziom jakości
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
oczyszczone przez
affinity chromatography
reaktywność gatunkowa
human, mouse, rat
reaktywność gatunkowa (przewidywana na podstawie homologii)
opossum (based on 100% sequence homology), horse (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), pig (based on 100% sequence homology)
metody
immunohistochemistry: suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
mouse ... Tbr1(21375)
Opis ogólny
Tbr1 gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Tbr1, a putative transcription factor known to be expressed in post-mitotic neurons, has been found highly expressed in glutamatergic early-born cortical neurons. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region the Tbr1 derived protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
Specyficzność
This antibody recognizes Tbr1.
Immunogen
Epitope: Internal
KLH-conjugated linear peptide corresponding to mouse Tbr1.
Zastosowanie
Anti-Tbr1 Antibody is an antibody against Tbr1 for use in WB, IH.
Immunohistochemistry Analysis: 1:100 dilution from a previous lot detected Tbr1 in mouse frontal cortex tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
Jakość
Evaluated by Western Blot in human fetal brain tissue lysate.
Western Blot Analysis: 0.025 µg/ml of this antibody detected Tbr1 on 10 µg of human fetal brain tissue lysate.
Western Blot Analysis: 0.025 µg/ml of this antibody detected Tbr1 on 10 µg of human fetal brain tissue lysate.
Opis wartości docelowych
~ 68 kDa is observed; however, UniProtKB/Swiss-Prot entry Q64336 (TBR1_MOUSE) lists a mass of 73.941 kDa
Postać fizyczna
Affinity purified
Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Komentarz do analizy
Control
Human fetal brain tissue lysate
Human fetal brain tissue lysate
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Leslie E W LaConte et al.
Human genetics, 137(3), 231-246 (2018-02-11)
Deletion and truncation mutations in the X-linked gene CASK are associated with severe intellectual disability (ID), microcephaly and pontine and cerebellar hypoplasia in girls (MICPCH). The molecular origin of CASK-linked MICPCH is presumed to be due to disruption of the
Shama Parween et al.
Frontiers in cellular neuroscience, 11, 415-415 (2018-01-10)
The nutrient responsive O-GlcNAcylation is a dynamic post-translational protein modification found on several nucleocytoplasmic proteins. Previous studies have suggested that hyperglycemia induces the levels of total O-GlcNAcylation inside the cells. Hyperglycemia mediated increase in protein O-GlcNAcylation has been shown to
Se-Jin Yoon et al.
Nature methods, 16(1), 75-78 (2018-12-24)
The differentiation of pluripotent stem cells in three-dimensional cultures can recapitulate key aspects of brain development, but protocols are prone to variable results. Here we differentiated multiple human pluripotent stem cell lines for over 100 d using our previously developed
Shinsuke Shibata et al.
Frontiers in neural circuits, 13, 29-29 (2019-05-28)
Recent improvements in correlative light and electron microscopy (CLEM) technology have led to dramatic improvements in the ability to observe tissues and cells. Fluorescence labeling has been used to visualize the localization of molecules of interest through immunostaining or genetic
Rachel Larsen et al.
eNeuro, 6(1) (2019-03-15)
GABAergic inhibitory neurons in the prefrontal cortex (PFC) play crucial roles in higher cognitive functions. Despite the link between aberrant development of PFC interneurons and a number of psychiatric disorders, mechanisms underlying the development of these neurons are poorly understood.
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