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Triptolide

Name: Triptolide
Brand: MM
Price: 580 PLN
Availability: InStock

from Tripterygium wilfordii, ≥95% (HPLC), DEVD-cleaving caspases activator, solid

Synonim(y):

Triptolide, Tripterygium wilfordii, PG490

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Rozmiar/SKU	Dostępność	Cena netto
1 mg	Przewidywany termin wysyłki16 września 2026zKuehne + Nagel Sp. z o.o.	580,00 zł
5 mg	Przewidywany termin wysyłki18 września 2026zKuehne + Nagel Sp. z o.o.	2310,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₀H₂₄O₆

Numer CAS:

38748-32-2

Masa cząsteczkowa:

360.40

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00210565

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

580,00 zł

Przewidywany termin wysyłki16 września 2026Szczegóły

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Właściwości

Nazwa produktu

Triptolide, Tripterygium wilfordii, A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

Quality Segment

100

description

RTECS - YK7751000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O1[C@@]32[C@]5(O[C@H]5C[C@@H]6[C@@]3(CCC7=C6COC7=O)C)[C@@H]([C@]4(O[C@H]4[C@@H]21)C(C)C)O

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key

DFBIRQPKNDILPW-CIVMWXNOSA-N

Opis

General description

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activate DEVD-cleaving caspases

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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Ta pozycja	523310	499610	529685
Sigma-Aldrich 645900 Triptolide, Tripterygium wilfordii	Sigma-Aldrich 523310 Pterostilben, Pterocarpus marsupium	Sigma-Aldrich 499610 (5Z)-7-Oxozeaenol, Curvularia sp.	Sigma-Aldrich 529685 Prodigiosin Serratia marcescens
description A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.	description A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, antiproliferative, and hypoglycemic properties.	description (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).	description A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance.
form solid	form solid	form solid	form solid
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
storage condition OK to freeze, protect from light	storage condition protect from light, OK to freeze	storage condition protect from light, OK to freeze	storage condition OK to freeze, protect from light