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616373

Tpl2 Kinase Inhibitor

Name: Tpl2 Kinase Inhibitor
Brand: MM
Price: 937 PLN
Availability: InStock

The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonim(y):

Tpl2 Kinase Inhibitor, 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

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Do Państwa/SKU	Dostępność	Cena netto
1 mg	Przewidywany termin wysyłki13 lipca 2026zKuehne + Nagel Sp. z o.o.	937,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₁H₁₄ClFN₆

Numer CAS:

871307-18-5

Masa cząsteczkowa:

404.83

MDL number:

MFCD12405303

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

937,00 zł

Przewidywany termin wysyłki13 lipca 2026Szczegóły

Pomoc techniczna

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Właściwości

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Fc1c(cc(cc1)Nc2c3c(ncc2C#N)cnc(c3)NCc4cnccc4)Cl

InChI

1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)

InChI key

NMEUKWOOQOHUNA-UHFFFAOYSA-N

Opis

General description

A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC₅₀ = 50 nM). Displays significant selectivity over other related kinases (IC₅₀ = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC₅₀ = 700 nM and 8.5 µM, respectively).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Tpl2 Kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 50 nM against Tpl2 kinase

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5288.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Ta pozycja	616452	118510	218860
Sigma-Aldrich 616373 Tpl2 Kinase Inhibitor	Sigma-Aldrich 616452 TGF-β RI Kinase Inhibitor II	Sigma-Aldrich 118510 Inhibitor kinazy ATR II	Sigma-Aldrich 218860 Casein Kinase II Inhibitor VIII
description The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).	description -	description The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
form solid	form solid	form powder	form solid
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay ≥99% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL	solubility DMSO: 5 mg/mL, methanol: 5 mg/mL	solubility DMSO: 100 mg/mL	solubility DMSO: 50 mg/mL

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Klasa składowania

11 - Combustible Solids

wgk

WGK 2

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Lot/Batch Number

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