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616452

RepSox

Name: RepSox
Brand: MM
Price: 819 PLN

≥95% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem

Synonim(y):

TGF-β RI Kinase Inhibitor II, ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

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Do Państwa/SKU	Dostępność	Cena netto
2 mg	Sprawdź dostępność w koszyku	819,00 zł
200 mg	Przewidywany termin wysyłki05 października 2026zKuehne + Nagel Sp. z o.o.	75 280,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₇H₁₃N₅

Numer CAS:

446859-33-2

Masa cząsteczkowa:

287.32

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD09037561

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

819,00 zł

Sprawdź dostępność w koszyku

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Właściwości

Nazwa produktu

TGF-β RI Kinase Inhibitor II, TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).

Quality Segment

100

assay

≥95% (HPLC)

form

solid

potency

23 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 5 mg/mL, methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[nH]1ncc(c1c4nc(ccc4)C)c2nc3c(nccc3)cc2

InChI

1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

InChI key

LBPKYPYHDKKRFS-UHFFFAOYSA-N

Opis

General description

A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC₅₀ = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC₅₀ >16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
ALKS binding

Product competes with ATP.

Secondary Target
ALK 5 auto phosphorylation (IC₅₀ = 4 nM)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.
Ichida, J. K., et al. 2009. Cell Stem Cell 5, 491.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	616453	616454	676481
Sigma-Aldrich 616452 TGF-β RI Kinase Inhibitor II	Sigma-Aldrich 616453 TGF-β RI Kinase Inhibitor III	Sigma-Aldrich 616454 TGF-β RI Kinase Inhibitor IV	Sigma-Aldrich 676481 VEGFR Tyrosine Kinase Inhibitor II
description TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).	description The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).	description The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 5 mg/mL, methanol: 5 mg/mL	solubility DMSO: 20 mg/mL, water: 3 mg/mL	solubility DMSO: 20 mg/mL	solubility DMSO: 5 mg/mL, methanol: soluble

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c