427218

FX11

≥96% (HPLC), solid, lactate dehydrogenase A inhibitor, Calbiochem^®

• Synonim(y): Lactate Dehydrogenase A Inhibitor, FX11
• Wzór empiryczny (zapis Hilla): C₂₂H₂₂O₄
• Numer CAS: 213971-34-7
• Masa cząsteczkowa: 350.41
• MDL number: MFCD00080561
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥96% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Lactate Dehydrogenase A Inhibitor, FX11, Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
• Quality Segment: 100
• assay: ≥96% (HPLC)
• form: solid
• potency: 8 μM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Opis

General description

A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; K_i = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.

Application

Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
LDHA

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Le, A., et al. 2011. Proc Natl Acad Sci USA.107, 2037.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable