219404

Cathepsin H, Human Liver

Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase.

• Synonim(y): Cathepsin H, Human Liver, CTSH, cat H, procathepsin h
• Numer CAS: 60748-73-4
• Numer WE: 3.4.22.16 (BRENDA, IUBMB)
• NACRES: NA.77
• UNSPSC Code: 12352202
• MDL number: MFCD09878269
• Specific activity: ≥200 mU/mg protein

Właściwości

• Quality Level: 100
• description: Merck USA index - 14, 1905
• form: liquid
• specific activity: ≥200 mU/mg protein
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, avoid repeated freeze/thaw cycles
• technique(s): activity assay: suitable
• color: colorless
• pH: 4.5
• solubility: soluble, water: soluble

Opis

General description

Research area: Cell signaling

Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.

Application

Cathepsin H has been used to determine the potential of aziridinyl peptides to act as inhibitors of this protein and potentially explore their therapeutic applications.

Biochem/physiol Actions

Cathepsin H, derived from human liver, serves dual functions as both an aminopeptidase and an endopeptidase. It plays a significant role in the catabolism of proteins within lysosomes. Cathepsin H is classified as an endoaminopeptidase because it can hydrolyze proteins, N-terminal substituted proteins, amino acid derivatives, and peptides with different chain lengths and N-terminal free amino acid derivatives. This protein is also observed to exhibit amidase and esterase activity.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 20 mM sodium acetate buffer, 1 mM EDTA, pH 4.5.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Note: 1 mU = 1 milliunit.

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol H-Arg-βNA per min at 40°C, pH 6.8.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 2