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Merck

178385

Apocynin

≥98% (GC), powder, NADPH oxidase inhibitor, Calbiochem®

Synonim(y):

4-hydroksy-3-metoksyacetofenon, acetowanilon, inhibitor oksydazy NADPH V, inhibitor NOX V

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1 G

576,00 zł

576,00 zł


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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C9H10O3
Numer CAS:
Masa cząsteczkowa:
166.17
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:

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Nazwa produktu

Apocynin, A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

SMILES string

O(C)c1c(ccc(c1)C(=O)C)O

InChI

1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

InChI key

DFYRUELUNQRZTB-UHFFFAOYSA-N

description

Merck USA index - 14, 741

assay

≥98% (GC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white to brown

solubility

DMSO: 10 mg/mL
ethanol: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

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Ta pozycja
PHL83252A10809W508454
Apocynin phyproof® Reference Substance

PHL83252

Apocynin

assay

≥98% (GC)

assay

≥95.0% (HPLC)

assay

98%

assay

≥98%

form

powder

form

solid

form

powder

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

PhytoLab

manufacturer/tradename

-

manufacturer/tradename

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

400

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

-

solubility

DMSO: 10 mg/mL, ethanol: 20 mg/mL

solubility

-

solubility

-

solubility

-

Disclaimer

Toxicity: Irritant (B)

Biochem/physiol Actions

Cell permeable: yes
Primary Target
NADPH oxidase
Product does not compete with ATP.
Reversible: no

General description

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).

Other Notes

Abid, M.R., et al. 2000. FEBS Lett.486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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pictograms

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signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

11 - Combustible Solids

wgk

WGK 2


Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Nagat Frara et al.
PloS one, 18(6), e0287212-e0287212 (2023-06-23)
Roles of redox signaling in bladder function is still under investigation. We explored the physiological role of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) in regulating bladder function in humans and dogs. Mucosa-denuded bladder smooth
Nguyen Mai et al.
Journal of neurochemistry, 168(5), 899-909 (2024-02-01)
Cofilactin rods (CARs), which are 1:1 aggregates of cofilin-1 and actin, lead to neurite loss in ischemic stroke and other disorders. The biochemical pathways driving CAR formation are well-established, but how these pathways are engaged under ischemic conditions is less
Yangyang Ding et al.
Nature communications, 14(1), 4829-4829 (2023-08-11)
Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of MTH1 in platelets are not known. Here, we show MTH1 expression
Kendra M Prutton et al.
Free radical biology & medicine, 196, 11-21 (2023-01-14)
Cellular redox state directs differentiation of induced pluripotent stem cells (iPSC) by energy metabolism control and ROS generation. As oxidative stress and mitochondrial dysfunction have been extensively reported in Down syndrome (DS), we evaluated mitochondrial phenotypes and energy metabolism during
Ji-Hee Kim et al.
International journal of molecular sciences, 25(11) (2024-06-19)
Urban air pollution, a significant environmental hazard, is linked to adverse health outcomes and increased mortality across various diseases. This study investigates the neurotoxic effects of particulate matter (PM), specifically PM2.5 and PM10, by examining their role in inducing oxidative

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