14-813
UbcH7 Conjugating Enzyme, 100 µg
UbcH7 is a class I enzyme which functions in the stress response & the control of transcription factors. The enzyme is ubiquitously expressed with high levels of expression seen in adult muscle.
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About This Item
Kod UNSPSC:
12352204
eCl@ss:
32160405
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
Próba
>95% (SDS-PAGE)
masa cząsteczkowa
Mw 18 kDa
producent / nazwa handlowa
Upstate®
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
informacje o genach
human ... UBE2G2(7327)
Opis ogólny
Product Source: Recombinant human UbcH7 Conjugating Enzyme expressed in E. coli.
UbcH7 is a class I enzyme which functions in the stress response and the control of transcription factors. The enzyme is ubiquitously expressed with high levels of expression seen in adult muscle. It has been demonstrated to participate in the ubiquitinylation of p53, c-Fos and NF-κB. UbcH7 is one of two E2s (UbcH5 being the other) with which HECT domain proteins interact with UbcH7 being able to efficiently substitute for UbcH5 in E6-AP-dependent ubiquitinylation. Typical enzyme concentration to support conjugation in vitro is 100nM to 1μM depending upon conditions.
Postać fizyczna
Purified using Ni2+ chelation chromatography with Ni2+ in limiting concentration.
Przechowywanie i stabilność
Stable for 1 year at -80°C from date of shipment. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80°C.
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
K K Chung et al.
Nature medicine, 7(10), 1144-1150 (2001-10-09)
Parkinson disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies). Mutations in alpha-synuclein (A53T, A30P) and parkin cause familial Parkinson disease. Both these proteins are found in Lewy
U Nuber et al.
The Journal of biological chemistry, 271(5), 2795-2800 (1996-02-02)
E6-AP, a 100-kDa cellular protein, was originally identified through its interaction with the E6 protein of the oncogenic human papillomavirus types 16 and 18. The complex of E6-AP and E6 specifically interacts with p53 and mediates ubiquitination of p53 in
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