116850

Inhibitor cyklazy adenylowej typu V, NKY80

The Adenylyl Cyclase Type V Inhibitor, NKY80, also referenced under CAS 299442-43-6, controls the biological activity of Adenylyl Cyclase Type V. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Synonim(y): 2-Amino-7-(furanylo)-7,8-dihydro-5(6H)-chinazolinon
• Wzór empiryczny (zapis Hilla): C₁₂H₁₁N₃O₂
• Numer CAS: 299442-43-6
• Masa cząsteczkowa: 229.23
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD02026323
• Assay: ≥97% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: pale orange
• solubility: DMSO: 200 mg/mL, methanol: 5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Nc1nc2c(cn1)C(=O)CC(C2)c3[o]ccc3
• InChI: 1S/C12H11N3O2/c13-12-14-6-8-9(15-12)4-7(5-10(8)16)11-2-1-3-17-11/h1-3,6-7H,4-5H2,(H2,13,14,15)
• InChI key: SOJUSNIBPPMLCC-UHFFFAOYSA-N

Opis

General description

A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.

A cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G₅α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Adenylate cyclase (AC) type V isoform

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Onda, T., et al. 2001. J. Biol. Chem.276, 47785.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable