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Merck

780200C

Avanti

16:0 PE MCC

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

Synonim(y):

1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

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About This Item

Wzór empiryczny (zapis Hilla):
C49H86N2O11PNa
Numer CAS:
Masa cząsteczkowa:
933.18
Kod UNSPSC:
12352211
NACRES:
NA.25

Próba

>99% (TLC)

Postać

liquid

opakowanie

pkg of 1 × 2.5 mL (780200C-25mg)

producent / nazwa handlowa

Avanti Research - A Croda Brand 780200C

stężenie

10 mg/mL (780200C-25mg)

Zastosowanie

advanced drug delivery

Warunki transportu

dry ice

temp. przechowywania

−20°C

Opis ogólny

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (16:0 PE MCC) is a lipid that comprises phosphoethanolamine linked to two palmitic acid by its phosphate group and to a maleimide moiety through its amino group. The maleimide group is a thiol acceptor and 16:0 PE MCC is a maleimide-based lipidating reagent.

Zastosowanie

16:0 PE MCC (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-4-(p-maleimidomethyl)cyclohexane-carboxamide) may be used:
  • in the preparation of liposomes for conjugation with human immune deficiency virus (HIV-1) envelope glycoprotein trimers
  • in the preparation of oligonucleotide-modified vesicles
  • in the functionalization of the flat silicon wafers
  • in lipid vesicle preparation

Działania biochem./fizjol.

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide](1,2-Bis(diphenylphosphino)ethane (DPPE)-MCC) in functionalized liposomes aids in covalent attachment via the maleimide group. It acts as a vehicle in peptide transport studies.

Opakowanie

5 mL Clear Glass Sealed Ampule (780200C-25mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organy docelowe

Central nervous system

Klasa zagrożenia wodnego (WGK)

WGK 3


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Malin Edvardsson et al.
Analytical chemistry, 81(1), 349-361 (2008-11-28)
A novel setup was recently developed, combining quartz crystal microbalance with dissipation monitoring (QCM-D) and optical reflectometry for measurements on one and the same surface of, for example, biomolecular adlayers and interactions ( Rev. Sci. Instr. 2008 , 79 075107
J T Elliott et al.
Bioconjugate chemistry, 11(6), 832-841 (2000-11-23)
Two maleimide-containing diacylglycerol derivatives were synthesized to permit the anchoring of short peptides and longer polypeptides to phospholipid bilayers and membranes. The maleimide was introduced at the site normally occupied by a phospholipid headgroup. The first lipid, the dipalmitoyl ester
Xiaoming Zhang et al.
Biochemical and biophysical research communications, 349(3), 920-924 (2006-09-15)
Human serum albumin (HSA) patterns have been successfully fabricated for the deposition of lipid bilayer, 1,2-dimyristoyl-sglycerophosphate (DMPA), by making use of the micro-contact printing (microCP) technique and liposome fusion. Confocal laser scanning microscopy (CLSM) results indicate that lipid bilayer has
K Gradauer et al.
Journal of controlled release : official journal of the Controlled Release Society, 172(3), 872-878 (2013-10-22)
The aim of the present study was the in vivo evaluation of thiomer-coated liposomes for an oral application of peptides. For this purpose, salmon calcitonin was chosen as a model drug and encapsulated within liposomes. Subsequently, the drug loaded liposomes
Bärbel Lorenz et al.
Biophysical chemistry, 150(1-3), 54-63 (2010-03-12)
A versatile model system to study membrane-membrane interactions in great detail is introduced. Based on colloidal probe microscopy with membrane covered spherical probes attached to tip-less cantilevers the interaction forces and adhesion energies are quantified down to single molecule resolution.

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