MAPK8
mitogen-activated protein kinase 8
Synonimy:
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Gatunek:
Human MAPK8 (5599), Mouse Mapk8 (26419), Rat Mapk8 (116554), chicken MAPK8 (423778), cow MAPK8 (539941), Goat MAPK8 (100861087), domestic cat MAPK8 (101091310), Horse MAPK8 (100051798), dog MAPK8 (477746), Domestic Rabbit MAPK8 (100346929) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(5599) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
- Mouse(26419) mitogen-activated protein kinase 8
- Rat(116554) mitogen-activated protein kinase 8
- chicken(423778) mitogen-activated protein kinase 8
- cow(539941) mitogen-activated protein kinase 8
- Goat(100861087) mitogen-activated protein kinase 8
- domestic cat(101091310) mitogen-activated protein kinase 8
- Horse(100051798) mitogen-activated protein kinase 8
- dog(477746) mitogen-activated protein kinase 8
- Domestic Rabbit(100346929) mitogen-activated protein kinase 8
- sheep(101116201) mitogen-activated protein kinase 8
- domestic guinea pig(100722333) mitogen-activated protein kinase 8
- naked mole-rat(101715259) mitogen-activated protein kinase 8
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Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Numer produktu
Opis
Gatunek
Cell-Based ELISA for detecting phospho-JNK (pThr183 / pTyr185) in cultured cell lines, 96 assays,
Gatunek
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
Gatunek
rat, human, mouse
Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-MAPK8 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human, rat
Zastosowanie
immunofluorescence
western blot
western blot
Anti-JNK1 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-phospho-JNK1/2 (pThr183/pTyr185) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human, rat
Zastosowanie
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
PhosphoDetect Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb, liquid, Calbiochem®,
Reaktywność gatunkowa
caenorhabditis elegans, drosophila, chicken, human, mouse, rat
Zastosowanie
Przeciwciało anty-fosfo-JNK1/2-T183/Y185produkowane u królików, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot
Small Molecule - Inhibitor
Proteins
Numer produktu
Opis
Gatunek
JNK1, active, GST tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,
Gatunek
mouse
Białko JNK1α1/SAPK1c, aktywne, 10 µg, Active, recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag, for use in Kinase Assays.,
Gatunek
human
Białko JNK1α1/SAPK1c, nieaktywne, 50 g, Unactive, N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c, for use in Kinase Assays.,
Gatunek
human