PTEN
phosphatase and tensin homolog
Synonimy:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Gatunek:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), naked mole-rat Pten (101714930), domestic guinea pig Pten (100723659), sheep PTEN (101119351), cow PTEN (540786), domestic cat PTEN (101091813), dog PTEN (403832)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- naked mole-rat(101714930) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-PTEN antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot
western blot
Anti-PTEN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
canine, human, mouse, rat
Zastosowanie
ELISA
western blot
western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-phospho-PTEN (pSer380/pThr382/pThr383) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse
Zastosowanie
ELISA
western blot
western blot