D5376
Dextran from Leuconostoc mesenteroides
average mol wt 1,500,000-2,800,000
Synonym(s):
6-O-(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-D-glucose, Manninotriose
About This Item
biological source
bacterial (Leuconostoc mesenteroides)
Quality Level
form
powder
optical activity
[α]/D 199°
mol wt
average mol wt 1,500,000-2,800,000
technique(s)
gel permeation chromatography (GPC): suitable
color
white
application(s)
advanced drug delivery
agriculture
life science and biopharma
microbiology
storage temp.
2-8°C
InChI
1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
InChI key
FZWBNHMXJMCXLU-UHFFFAOYSA-N
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General description
Application
Dextrans of less than 60,000Da are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (1500-2800), a high molecular weight dextran, may be used to induce blood aggregation and as a high viscosity plasma expander (HVPE).
Biochem/physiol Actions
- Osmotic Balance: Dextran helps maintain osmotic balance by increasing the solute concentration in a solution. This prevents excessive water movement across cell membranes, thus maintaining cell integrity and function.
- Cryoprotection: Dextran acts as a cryoprotectant by forming a protective barrier around cells and tissues during freezing. This barrier inhibits the formation of ice crystals, which can damage cell membranes and structures.
- Viscosity Control: Dextran can alter the viscosity of solutions by increasing the molecular weight of the solution. This change in viscosity affects the flow properties of the solution, making it useful for controlling the thickness of solutions in various processes.
- Drug Delivery: Modified dextran serves as a carrier for controlled drug delivery. Dextran can encapsulate drugs and release them gradually, enhancing drug solubility and controlling the release profiles to improve therapeutic outcomes.
- Gel Electrophoresis: Dextran increases the density of sample-loading solutions in gel electrophoresis. This increased density helps samples sink into the gel matrix, allowing for more precise separation of molecules based on size and charge during electrophoresis.
- Enzyme Stabilization: Dextran stabilizes enzymes by providing a protective environment. It forms a stable matrix around enzymes, enhancing their activity and extending their lifespan in various biochemical reactions. This protection prevents enzyme denaturation and inactivation, allowing enzymes to function more effectively.
Features and Benefits
- Dextran with an average molecular weight range of 1,500,000-2,800,000
- Freely soluble in Water, DMSO, formamide, ethylene glycol, and glycerol
- Versatile and adaptable for a wide variety of laboratory and research applications
Preparation Note
Other Notes
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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