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D4626

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides

average mol wt 15,000-30,000

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About This Item

Linear Formula:
(C6H10O5)n
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

form

powder

optical activity

[α]/D 199°

mol wt

average mol wt 15,000-30,000

color

white

solubility

water: 20 mg/mL, clear, colorless to faintly yellow

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI key

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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General description

Dextran is a branched glucan composed of linear α(1→6) linked glucose units and α (1→3) link initiated branches. Dextran ranges in size from 10,000 to 150,000 kDa.

Application

Dextrans are used in many applications as volume extenders, osmotic pressure regulators, stabilizers, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextrans of less than 60,000 kDa are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (15,000-30,000), a low molecular weight dextran, may be used to study processes such as transient plasma membrane permeabilization. Dextran (15,000-30,000), may be used as a sugar based crowding agent in protein packing and folding studies.
Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.

Preparation Note

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eugen Sisu et al.
Rapid communications in mass spectrometry : RCM, 20(2), 209-218 (2005-12-15)
A combined methodology for obtaining at the preparative scale and characterization by nanoelectrospray ionization (nanoESI) quadrupole time-of-flight (QTOF) mass spectrometry (MS) and tandem MS (MS/MS) of linear polysaccharides modified at the reducing end is presented. Two polydisperse maltodextrins (1000 and
R J Stenekes et al.
Biomaterials, 22(13), 1891-1898 (2001-06-09)
In this paper, a novel method is presented for the preparation of dextran hydrogels and microspheres, based on crystallization. Although dextrans are known to be well soluble in water, precipitation was observed in concentrated aqueous solutions of low molecular weight
Thomas Rath et al.
Nephron. Clinical practice, 114(1), c81-c88 (2009-11-06)
Intravenous iron supplementation is a basic principle in the therapy of haemodialysis (HD) patients with renal anaemia. In the Iron Dextran in Renal Anaemia (IDIRA) study, we analysed the efficacy of a therapy with low-molecular-weight iron dextran (LMW-ID) in stable
Molecular Weight Effects on the Miscibility Behavior of Dextran and Maltodextrin with Poly(vinylpyrrolidone).
Van Eerdenbrugh B, Taylor LS.
Pharmaceut. Res., doi: 10-doi: 10 (2012)
Yuichi Ozaki et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(4), 922-927 (2012-02-04)
Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, the former requires injection of contrast media for image acquisition. The increased total amount of contrast media for FD-OCT image acquisition may

Protocols

Dextran polymer details: composed mainly of alpha-D-(1-6) linkages with varied branch lengths.

Dextran polymer details: composed mainly of alpha-D-(1-6) linkages with varied branch lengths.

Dextran polymer details: composed mainly of alpha-D-(1-6) linkages with varied branch lengths.

Dextran polymer details: composed mainly of alpha-D-(1-6) linkages with varied branch lengths.

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