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1672304

USP

Torsemide

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H20N4O3S
CAS Number:
56211-40-6
Molecular Weight:
348.42
NACRES:
NA.24
PubChem Substance ID:
329751356
UNSPSC Code:
41116107
MDL number:
MFCD00866166
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grade

pharmaceutical primary standard

API family

torsemide

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChI key

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Torsemide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Torsemide Tablets
  • Torsemide Compounded Oral Suspension

Biochem/physiol Actions

Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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This Item
Y0000462T3202Y0000461
Torsemide United States Pharmacopeia (USP) Reference Standard

USP

1672304

Torsemide

Torasemide for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000462

Torasemide for system suitability

Torsemide ≥98% (HPLC), solid

Sigma-Aldrich

T3202

Torsemide

Torasemide anhydrous European Pharmacopoeia (EP) Reference Standard

Y0000461

Torasemide anhydrous

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

EDQM

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

format

neat

format

neat

format

-

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

API family

torsemide

API family

torasemide

API family

-

API family

torasemide

Gene Information

human ... SLC12A1(6557)

Gene Information

human ... SLC12A1(6557)

Gene Information

human ... SLC12A1(6557)

Gene Information

human ... SLC12A1(6557)

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Repr. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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J S Blose et al.
The Annals of pharmacotherapy, 29(4), 396-402 (1995-04-01)
To review the clinical pharmacology of torsemide and to compare it with currently available loop diuretics, particularly furosemide. An English-language MEDLINE search, 1985 to October 1994, was used to identify pertinent literature, including review articles. Data from scientific literature were
S F Fowler et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 52(16), 1771-1780 (1995-08-15)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of torsemide are reviewed. Torsemide belongs to the pyridine-sulfonylurea class of loop diuretics. Its primary site of activity is the thick ascending limb of the loop of Henle, where
James J DiNicolantonio
Future cardiology, 8(5), 707-728 (2012-09-28)
Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure (HF), yet torsemide has been shown to have less inter- and intra-individual variation in bioavailability and a longer duration of action compared with furosemide. Thus
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Global Trade Item Number

SKUGTIN
1672304-200MG04061833855652

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