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Bisdesmethoxycurcumin

Name: Bisdesmethoxycurcumin
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₆O₄

CAS Number:

33171-05-0

Molecular Weight:

308.33

MDL number:

MFCD03419284

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

curcumin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(cc2)O

InChI

1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+

InChI key

PREBVFJICNPEKM-YDWXAUTNSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Bisdesmethoxycurcumin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Curcuminoids
Curcuminoids Capsules
Curcuminoids Tablets
Powdered Turmeric
Powdered Turmeric Extract
Turmeric

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	PHR3434	PHL89582	90594
USP 1075305 Bisdesmethoxycurcumin	Supelco PHR3434 Bisdesmethoxycurcumin	PHL89582 Bisdemethoxycurcumin	Supelco 90594 Bisdemethoxycurcumin
grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade primary reference standard	grade analytical standard
manufacturer/tradename USP	manufacturer/tradename -	manufacturer/tradename PhytoLab	manufacturer/tradename -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical	application(s) food and beverages	application(s) food and beverages
format neat	format -	format neat	format neat
storage temp. −20°C	storage temp. -10 to -25°C	storage temp. -	storage temp. -
API family curcumin	API family -	API family -	API family -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes.

Sudha Ponnusamy et al.

Food chemistry, 135(4), 2638-2642 (2012-09-18)

Curcuma longa rhizome is used extensively in culinary preparations in Far East and South-East Asia. Health benefits of curcuminoids from C. longa as antioxidants, anti-cancer and anti-inflammatory molecules have been well documented. We report here for the first time that

The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer.

Y-L Liu et al.

Current cancer drug targets, 11(9), 1098-1110 (2011-09-22)

Hypermethylation of the Wnt inhibitory factor-1 (WIF-1) promoter has been implicated in the overactivation of the Wnt pathway in human lung cancer. Curcuminoids exert anti-cancer effects and have been reported to act as hypomethylating agents. Previously, we have investigated and

Curcumins promote monocytic gene expression related to β-amyloid and superoxide dismutase clearance.

J R Cashman et al.

Neuro-degenerative diseases, 10(1-4), 274-276 (2011-12-14)

Neurodegenerative diseases are associated with accumulation of modified proteins or peptides including amyloid-β (Aβ) in Alzheimer's disease (AD), and misfolded superoxide dismutase-1 (SOD-1) in amyotrophic lateral sclerosis (ALS). Clearance of Aβ or SOD-1 by the innate immune system may be

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Global Trade Item Number

SKU	GTIN
1075305-30MG	04061838675248

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