This product has not been tested for the presence of endotoxins. Currently, an endotoxin tested product option is not available.
C4369
Calcipotriol hydrate
≥98% (HPLC), powder, Vitamin D3 analog
Synonym(s):
(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol, Calcipotriene
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About This Item
Empirical Formula (Hill Notation):
C27H40O3 · xH2O
CAS Number:
Molecular Weight:
412.60 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Calcipotriol hydrate, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 15 mg/mL, clear
storage temp.
room temp
SMILES string
O.C[C@H](\C=C\[C@@H](O)C1CC1)C2CCC3\C(CCC[C@]23C)=C\C=C4\C[C@@H](O)C[C@H](O)C4=C
InChI
1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
InChI key
XBKHACNRWFKJNC-MANNPBRJSA-N
Biochem/physiol Actions
Calcipotriol is a synthetic derivative of calcitriol, or Vitamin D.
Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form powder | form powder | form powder | form - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. room temp | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 15 mg/mL, clear | solubility DMSO: 3 mg/mL, clear (warmed) | solubility DMSO: >10 mg/mL | solubility - |
signalword
Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1B - STOT RE 1
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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