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C0495

CDK2/Cyclin A2, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

CCN1, CCNA, p33 (CDK2)

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
buffered aqueous glycerol solution
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
CDK2 subunit ~58 kDa, cyclin A2 ~78 kDa
Pricing and availability is not currently available.
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recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

778-1052 nmol/min·mg

mol wt

CDK2 subunit ~58 kDa, cyclin A2 ~78 kDa

UniProt accession no.

P20248, P24941

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CCNA2(890), CDK2(1017)

Biochem/physiol Actions

CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B).CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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SRP5345C0244C0999
CDK2/Cyclin A2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C0495

CDK2/Cyclin A2, active, GST tagged human

CyclinE1, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5345

CyclinE1, GST tagged human

CDK1/Cyclin A2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C0244

CDK1/Cyclin A2, active, GST tagged human

CDK2/CyclinE1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C0999

CDK2/CyclinE1, active, GST tagged human

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

mol wt

CDK2 subunit ~58 kDa, cyclin A2 ~78 kDa

mol wt

~73 kDa

mol wt

CDK1 subunit ~59 kDa, cyclin A2 ~78 kDa

mol wt

CDK2 subunit ~58 kDa, cyclin E1 ~73 kDa

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

Gene Information

human ... CCNA2(890), CDK2(1017)

Gene Information

human ... CCNE1(898)

Gene Information

human ... CCNA2(890), CDK1(983)

Gene Information

human ... CCNE1(898), CDK2(1017)

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCR0689
SLBP3936V
SLBH5110V
SLBD0897V
041M1000V

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Anna Siegert et al.
Protein science : a publication of the Protein Society, 30(7), 1326-1336 (2021-01-17)
In Parkinson's disease with dementia, up to 50% of patients develop a high number of tau-containing neurofibrillary tangles. Tau-based pathologies may thus act synergistically with the α-synuclein pathology to confer a worse prognosis. A better understanding of the relationship between
Haojie Huang et al.
Science (New York, N.Y.), 314(5797), 294-297 (2006-10-14)
The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell cycle arrest and DNA repair. However, whether CDK2 also influences the survival of cells under
B Levkau et al.
Molecular cell, 1(4), 553-563 (1998-07-14)
Apoptosis of human endothelial cells after growth factor deprivation is associated with rapid and dramatic up-regulation of cyclin A-associated cyclin-dependent kinase 2(cdk2) activity. In apoptotic cells, the C termini of the cdk inhibitors p21Cip1/Waf1 and p27Kip1 are truncated by specific
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Global Trade Item Number

SKUGTIN
C0495-10UG04061837753176

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