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Merck
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Key Documents

1370101

USP

洛匹那韦

United States Pharmacopeia (USP) Reference Standard

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About This Item

经验公式(希尔记法):
C37H48N4O5
分子量:
628.80
分類程式碼代碼:
41116107
NACRES:
NA.24

生物源

synthetic

等級

pharmaceutical primary standard

agency

USP/NF

API 家族

lopinavir

形狀

powder

包裝

pkg of 350 mg

製造商/商標名

USP

儲存條件

protect from light

顏色

white to off-white

mp

255.2-260.6 °F (124—127°C)

溶解度

chloroform: soluble
isopropanol: soluble
methanol: freely soluble
methylene chloride: freely soluble
water: practically insoluble

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

InChI

1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI 密鑰

KJHKTHWMRKYKJE-SUGCFTRWSA-N

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一般說明

Lopinavir is an antiretroviral agent and a protease inhibitor indicated for the management of human immunodeficiency virus (HIV) infection. It is a key component of Kaletra, the co-formulation of lopinavir and ritonavir.

應用

Lopinavir may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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访问文档库

Lopinavir USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(6), 2610-2610 (2020)
Simultaneous determination of indinavir, ritonavir and lopinavir (ABT 378) in human plasma by high-performance liquid chromatography
Ray J, et al.
Journal of Chromatography. B, Biomedical Applications, 775(2), 225-230 (2002)
Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography
Rebiere H, et al.
Journal of Chromatography. B, Biomedical Applications, 850(1-2), 376-383 (2007)
Validation and application of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid-liquid extraction
Wang PG, et al.
Journal of Chromatography A, 1130(2), 302-307 (2006)
Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy
Lambert JS, et al.
HIV Medicine, 12(3), 166-173 (2011)

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