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重組細胞
expressed in E. coli
品質等級
形狀
buffered aqueous solution
濃度
≥500 units/mL
UniProt登錄號
儲存溫度
2-8°C
基因資訊
Escherichia coli K12 ... deoA(948901)
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一般說明
胸苷磷酸化酶抑制血管平滑肌细胞增殖。
應用
胸苷磷酸化酶已用于评估TAS-102治疗晚期实体瘤患者的研究。 胸苷磷酸化酶也已用于研究FP3蛋白对原发性结肠癌患者来源的肿瘤组织异种移植模型的抗肿瘤作用。
生化／生理作用
一种对胸腺嘧啶可逆性转化为胸腺嘧啶进行催化的酶。胸苷磷酸化酶是嘧啶核苷挽救途径的一部分。该途径允许嘧啶碱基被回收用于核苷酸生物合成，而1-磷酸戊糖被转化为磷酸戊糖分流和糖酵解的中间体。 大肠埃希菌胸苷磷酸化酶与人序列具有40%的序列同源性，已发现该序列与血管生成剂血小板衍生的内皮生长因子相同。 在鸡绒膜尿囊膜测定中，纯化的大肠埃希菌酶已显示出刺激血管生长的作用。
單位定義
一个单位将在25℃的pH 7.4下每分钟将1.0 μmole的胸苷和磷酸盐分别转化为胸腺嘧啶和2-脱氧核糖1-磷酸。
外觀
溶于含2 mM尿嘧啶、0.02%叠氮化钠和牛血清白蛋白的0.5 M磷酸钾溶液
準備報告
从大肠埃希菌克隆并在过表达大肠埃希菌中产生
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Journal of pharmaceutical and biomedical analysis, 72, 16-24 (2012-11-14)
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