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重組細胞
expressed in E. coli
品質等級
無菌
0.2 μm filtered
形狀
buffered aqueous solution
濃度
≥900 units/mL
UniProt登錄號
儲存溫度
2-8°C
基因資訊
Escherichia coli K12 ... deoA(948901)
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一般說明
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation.
應用
Thymidine phosphorylase has been used in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy. Thymidine phosphorylase has also been used in a study to investigate implications for the clinical efficacy of nucleoside analogues.
生化／生理作用
一种对胸腺嘧啶可逆性转化为胸腺嘧啶进行催化的酶。胸苷磷酸化酶是嘧啶核苷挽救途径的一部分。该途径允许嘧啶碱基被回收用于核苷酸生物合成，而1-磷酸戊糖被转化为磷酸戊糖分流和糖酵解的中间体。 大肠埃希菌胸苷磷酸化酶与人序列具有40%的序列同源性，已发现该序列与血管生成剂血小板衍生的内皮生长因子相同。 在鸡绒膜尿囊膜测定中，纯化的大肠埃希菌酶已显示出刺激血管生长的作用。
單位定義
One unit will convert 1.0 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per min at pH 7.4 at 25°C.
外觀
Solution in 0.5 M potassium phosphate containing 2 mM uracil, 0.02% sodium azide and bovine serum albumin
準備報告
Cloned from E. coli and produced in overexpressing E. coli
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Agnieszka Zagórska et al.
Materials (Basel, Switzerland), 14(15) (2021-08-08)
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Several anti-angiogenic agents have been developed and some of them have been clinically applied in the tumor therapy. Anti-angiogenic therapy faces some hurdles: inherent or acquired resistance, increased invasiveness, and lack of biomarkers. Characterization of tumor endothelial markers may help
I Nishino et al.
Science (New York, N.Y.), 283(5402), 689-692 (1999-01-29)
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (mtDNA), which have been ascribed to a defect in communication between the nuclear and mitochondrial genomes. Examination of 12 MNGIE probands
J Gamez et al.
Neurology, 59(3), 455-457 (2002-08-15)
Clinical, biochemical, and genetic features of a Spanish family with mitochondrial neurogastrointestinal encephalomyopathy are reported. The proband presented with severe gastrointestinal dysmotility and the affected sister had extraocular muscle weakness. In both affected individuals, biochemical defects of thymidine phosphorylase and
Kamel El Omari et al.
The Biochemical journal, 399(2), 199-204 (2006-06-29)
HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism. HTP is implicated in angiogenesis and apoptosis and therefore is a prime target for drug design, including antitumour
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