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T2255

Sigma-Aldrich

三氟胸苷

≥99% (HPLC)

别名:

α,α,α-三氟胸苷, 2'-脱氧-5-三氟甲基尿苷, 三氟胸腺嘧啶脱氧核苷, 曲氟尿苷

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About This Item

经验公式（希尔记法）:
C10H11F3N2O5
CAS号:
70-00-8
分子量:
296.20
EC號碼:
200-722-8
MDL號碼:
MFCD00006534
分類程式碼代碼:
41106305
PubChem物質ID:
24900027
NACRES:
NA.51
价格与库存信息目前不能提供

生物源

synthetic

品質等級

100

化驗

≥99% (HPLC)

形狀

powder

mp

190-193 °C (lit.)

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F

InChI

1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

InChI 密鑰

VSQQQLOSPVPRAZ-RRKCRQDMSA-N

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應用

三氟胸苷已用作选择性培养基组分，用于筛选淋巴瘤细胞、[1]人淋巴母细胞样细胞TK6[2]和小鼠淋巴瘤细胞L5178Y中的胸苷激酶(TK)突变体。[3]

生化／生理作用

三氟胸苷(TFT)是一种胸苷类似物[4]，对光敏感。[1]TFT可作为胸苷激酶底物，用于研究该酶的特异性和动力学。[5]磷酸化TFT可掺入DNA，诱导DNA损伤，[6]因而TFT适合用于研究DNA修复机制。TFT也可用于研究胸苷酸合成酶抑制机制[5]和筛选胸苷激酶突变基因[1]。它对胃肠道癌具有抗肿瘤活性[7]，也可用于治疗疱疹病毒性角膜炎。[4]

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

象形圖

Health hazard
GHS08

訊號詞

Warning

危險聲明

H341,H351,H361d

危險分類

Carc. 2 - Muta. 2 - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK8225
BCCJ6756
BCCG7691
BCCD9525
BCCD1998

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