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产品名称
Bafilomycin A1 Ready Made Solution, 0.16 mM in DMSO, from Streptomyces griseus
生物来源
Streptomyces griseus
质量水平
表单
DMSO solution
浓度
0.16 mM in DMSO
运输
dry ice
储存温度
−20°C
SMILES字符串
O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C(=C\C(=C\[C@H]([C@H]([C@H](C\C(=C\C=C\[C@@H]2OC)\C)C)O)C)\C)\OC)C)C)O)C)C(C)C
InChI
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
一般描述
Bafilomycin A1, a macrolide antibiotic[1], belongs to the pleomacrolides family.[2] It acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.[3] BafA1 can inhibit the viability of MG63 osteosarcoma cells. It can also stimulate mitochondrial dysfunction.[1] BafA1 inhibits the proliferation of different types of cancer cells.[3]
应用
Bafilomycin A1 has been used:
- as an endosome acidification inhibitor to study the importance of endosome acidification in the extracellular vesicle uptake and cytosolic release of stably expressing NanoLuc luciferase-tagged Hsp70 (NLuc-Hsp70) in HeLa cells[4]
- as a vacuolar-type H+-ATPase (V-ATPase) inhibitor to study its effects on autophagic turnover of light chain 3 β (LC3-II) in mice[5]
- as an autophagy inhibitor to study its effects on primary rat liver sinusoidal endothelial cells (LSECs) defenestration[6]
生化/生理作用
Bafilomycin A1 inhibits autophagy. It may exhibit anti-tumorigenic, anti-parasitic, and anti-neurodegenerative effects.[7] Bafilomycin A1, found in lysosomes and endosomes prevents the acidification of these cell organelles.[8] It also participates in blocking autophagosome-lysosome fusion and autolysosome acidification, steps necessary for maintaining the autophagic flux and cellular homeostasis.[9]
Bafilomycin A1 is a macrolide antibiotic.
Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.
其他说明
Bafilomycin A1 solution is provided in concentration of 0.16 mM. Typical concentrations for use in cell culture are 50-100 nM.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Molecular basis of V-ATPase inhibition by bafilomycin A1
Wang R, et al.
Nature Communications (2021)
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways
Yan Y, et al.
Scientific Reports (2016)
Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells
Xie Z, et al.
Molecular medicine reports (2014)
Xiaoying Luo et al.
Cell death & disease, 9(5), 576-576 (2018-05-16)
Autophagy, interacting with actin cytoskeleton and the NO-dependent pathway, may affect the phenotype and function of endothelial cells. Moreover, caveolin-1 (Cav-1), as a structure protein in liver sinusoidal endothelial cells (LSECs), is closely related to autophagy. Hence, we aim to
Célia Fourrier et al.
Biochemical and biophysical research communications, 534, 107-113 (2020-12-15)
Measurement of autophagic flux in vivo is critical to understand how autophagy can be used to combat disease. Neurodegenerative diseases have a special relationship with autophagy, which makes measurement of autophagy in the brain a significant research priority. Currently, measurement of
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