推荐产品
生物源
synthetic (organic)
品質等級
化驗
≥99% (HPLC)
形狀
powder
mp
~300 °C (dec.) (lit.)
溶解度
DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow
SMILES 字串
Cn1cnc(N)c2ncnc12
InChI
1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChI 密鑰
FSASIHFSFGAIJM-UHFFFAOYSA-N
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應用
3-甲基腺嘌呤作为自噬抑制剂已用于：
- 使用转染人骨髓间充质干细胞(BM-MSC)检测自噬相关基因（Beclin 1，轻链3(LC3)和p62）的表达
- 协同顺铂(cisplatin)研究A2780cp细胞的自噬抑制会否影响顺铂诱导的细胞凋亡
- 研究多黏菌素(colistin)诱导的自噬和凋亡之间的相互作用
3-甲基腺嘌呤（3-MA）用于抑制和研究多种条件下自噬（溶酶体自我降解）和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶（PI-3K）阻断自噬体的形成来对自噬进行抑制。 3-MA通常以5 mM的浓度用作自噬抑制剂。
在癌症生成过程中核酸甲基化检测的标准品。
生化／生理作用
3-甲基腺嘌呤（3-MA）用于抑制和研究多种条件下自噬（溶酶体自我降解）和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶（PI-3K）阻断自噬体的形成来对自噬进行抑制。
準備報告
该产品可溶于DMF（10 mg/mL；可能需要温和受热）。 受热情况下，其可以30 mg/ml的浓度溶于水、95％乙醇或1 N NaOH，但在冷却后会从溶液中析出。 可在DMSO中配制100 mM的3-MA溶液。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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