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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
O=C(N)N(CC1)CCC1CC(N2CCC([C@H]3C(N=CC(Br)=C4)=C4CCC5=C3C(Br)=CC(Cl)=C5)CC2)=O
InChI
1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChI 密鑰
DHMTURDWPRKSOA-RUZDIDTESA-N
基因資訊
human ... FNTA(2339) , FNTB(2342)
一般說明
洛那法尼（SCH66336）是法呢基转移酶抑制剂（FTI）。K- 和 N-Ras 是法呢基转移酶的底物。
生化／生理作用
洛那法尼可防止 H-Ras 和其他法尼基化蛋白的翻译后脂质修饰。洛那法尼治疗导致微管成束、微管乙酰化增加、稳定和抑制微管动力学。
洛那法尼是法尼基转移酶的有效抑制剂，法尼基转移酶是负责蛋白质（包括 Ras）翻译后修饰的酶，可使蛋白质具有足够的疏水性，可转运至质膜。 法尼基化调节控制细胞存活、增殖和分化的信号级联反应，因此多种可能的用途不足为奇 一种蛋白质（包括 Ras）翻译后修饰的酶，可使蛋白质具有足够的疏水性，可转运至质膜 洛那法尼已被研究用于治疗早衰、各种癌症和 D 型肝炎。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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