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方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
InChI
1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChI key
XRKYMMUGXMWDAO-UHFFFAOYSA-N
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应用
KU-55933已被用作共济失调-毛细血管扩张症突变（ATM）抑制剂。
生化/生理作用
KU-55933是一种非常有效的共济失调毛细血管扩张症（A-T）突变（ATM）激酶特异性抑制剂。
KU-55933是一种非常有效的共济失调毛细血管扩张症（A-T）突变（ATM）激酶特异性抑制剂（IC50 = 13 nM）。KU-22933处理可增强癌细胞对电离辐射和细胞毒性药物的敏感性。化合物KU-22933能够阻断ATM介导的p53、gH2AX、NBS1和SMC1的磷酸化。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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